A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. The accumulation of amyloid-β (Aβ) protein and plaque formation in the brain are two major causes of AD. Interestingly, growing evidence demonstrates that the gut flora can alleviate AD by affecting amyloid prod...

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Detalles Bibliográficos
Autores principales: Huang, Li, Lu, Zhaogang, Zhang, Hexin, Wen, Hongyong, Li, Zongji, Liu, Qibing, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473151/
https://www.ncbi.nlm.nih.gov/pubmed/36336932
http://dx.doi.org/10.3233/JAD-220651
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author Huang, Li
Lu, Zhaogang
Zhang, Hexin
Wen, Hongyong
Li, Zongji
Liu, Qibing
Wang, Rui
author_facet Huang, Li
Lu, Zhaogang
Zhang, Hexin
Wen, Hongyong
Li, Zongji
Liu, Qibing
Wang, Rui
author_sort Huang, Li
collection PubMed
description Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. The accumulation of amyloid-β (Aβ) protein and plaque formation in the brain are two major causes of AD. Interestingly, growing evidence demonstrates that the gut flora can alleviate AD by affecting amyloid production and metabolism. However, the underlying mechanism remains largely unknown. This review will discuss the possible association between the gut flora and Aβ in an attempt to provide novel therapeutic directions for AD treatment based on the regulatory effect of Aβ on the gut flora.
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spelling pubmed-104731512023-09-02 A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora Huang, Li Lu, Zhaogang Zhang, Hexin Wen, Hongyong Li, Zongji Liu, Qibing Wang, Rui J Alzheimers Dis Review Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. The accumulation of amyloid-β (Aβ) protein and plaque formation in the brain are two major causes of AD. Interestingly, growing evidence demonstrates that the gut flora can alleviate AD by affecting amyloid production and metabolism. However, the underlying mechanism remains largely unknown. This review will discuss the possible association between the gut flora and Aβ in an attempt to provide novel therapeutic directions for AD treatment based on the regulatory effect of Aβ on the gut flora. IOS Press 2023-07-25 /pmc/articles/PMC10473151/ /pubmed/36336932 http://dx.doi.org/10.3233/JAD-220651 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Li
Lu, Zhaogang
Zhang, Hexin
Wen, Hongyong
Li, Zongji
Liu, Qibing
Wang, Rui
A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title_full A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title_fullStr A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title_full_unstemmed A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title_short A Novel Strategy for Alzheimer’s Disease Based on the Regulatory Effect of Amyloid-β on Gut Flora
title_sort novel strategy for alzheimer’s disease based on the regulatory effect of amyloid-β on gut flora
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473151/
https://www.ncbi.nlm.nih.gov/pubmed/36336932
http://dx.doi.org/10.3233/JAD-220651
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