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Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis

BACKGROUND: Penile size is considered a symbol of manhood and is a subjective problem for men, especially those with small penis syndrome. Penile augmentation was introduced to correct penile size problems from a medical, psychological, or esthetic point of view. Hyaluronic acid (HA) and polylactic...

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Autores principales: Kusumaputra, Ahmad, Setiawan, Muhammad R., Soebadi, Mohammad A., Wirjopranoto, Soetojo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473315/
https://www.ncbi.nlm.nih.gov/pubmed/37663705
http://dx.doi.org/10.1097/MS9.0000000000001094
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author Kusumaputra, Ahmad
Setiawan, Muhammad R.
Soebadi, Mohammad A.
Wirjopranoto, Soetojo
author_facet Kusumaputra, Ahmad
Setiawan, Muhammad R.
Soebadi, Mohammad A.
Wirjopranoto, Soetojo
author_sort Kusumaputra, Ahmad
collection PubMed
description BACKGROUND: Penile size is considered a symbol of manhood and is a subjective problem for men, especially those with small penis syndrome. Penile augmentation was introduced to correct penile size problems from a medical, psychological, or esthetic point of view. Hyaluronic acid (HA) and polylactic acid (PLA) are two types of augmentation agents that are popularly used today. However, no systematic studies and meta-analyses have compared these two modalities as penile augmentation agents. This study aimed to analyze the efficacy and safety of penile filler injections with HA compared to PLA. METHODS: This study was based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Articles examining the differences in efficacy and adverse events of the administration of HA and PLA in patients undergoing penile augmentation were systematically reviewed from the PubMed, Proquest, Web of Science, and Scopus databases. An odds ratio with a 95% CI was applied to measure the study outcome. The analysis was performed with RevMan 5.4 software. The risk of bias for each study was evaluated using the Risk of Bias v2 instrument from Cochrane. This research protocol is registered in the International Prospective Register of Systematic Reviews (PROSPERO) registry. RESULT: Four articles consisting of 283 research subjects were included in this study. The meta-analysis for penile girth enhancement after penile augmentation found significant results in the HA group compared to the PLA group (P=0.01). There was no difference in the level of satisfaction with penile appearance 4 weeks after penile augmentation in the HA group compared to the PLA group (P=0.79). HA was significantly superior in sexual satisfaction 12 weeks postpenile augmentation (P=0.0004). There was no difference in the incidence of pain after penile augmentation in the HA group compared to the PLA group (P=0.33). In the postaugmentation penile inflammation, there was no difference (P=0.98) in the HA group compared to the PLA group. CONCLUSION: There are differences in the efficacy of penile augmentation with the superiority of HA in increasing penile diameter and postaugmentation sexual satisfaction compared to PLA. There was no difference in the incidence of complications between using HA and PLA.
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spelling pubmed-104733152023-09-02 Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis Kusumaputra, Ahmad Setiawan, Muhammad R. Soebadi, Mohammad A. Wirjopranoto, Soetojo Ann Med Surg (Lond) Review Articles BACKGROUND: Penile size is considered a symbol of manhood and is a subjective problem for men, especially those with small penis syndrome. Penile augmentation was introduced to correct penile size problems from a medical, psychological, or esthetic point of view. Hyaluronic acid (HA) and polylactic acid (PLA) are two types of augmentation agents that are popularly used today. However, no systematic studies and meta-analyses have compared these two modalities as penile augmentation agents. This study aimed to analyze the efficacy and safety of penile filler injections with HA compared to PLA. METHODS: This study was based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Articles examining the differences in efficacy and adverse events of the administration of HA and PLA in patients undergoing penile augmentation were systematically reviewed from the PubMed, Proquest, Web of Science, and Scopus databases. An odds ratio with a 95% CI was applied to measure the study outcome. The analysis was performed with RevMan 5.4 software. The risk of bias for each study was evaluated using the Risk of Bias v2 instrument from Cochrane. This research protocol is registered in the International Prospective Register of Systematic Reviews (PROSPERO) registry. RESULT: Four articles consisting of 283 research subjects were included in this study. The meta-analysis for penile girth enhancement after penile augmentation found significant results in the HA group compared to the PLA group (P=0.01). There was no difference in the level of satisfaction with penile appearance 4 weeks after penile augmentation in the HA group compared to the PLA group (P=0.79). HA was significantly superior in sexual satisfaction 12 weeks postpenile augmentation (P=0.0004). There was no difference in the incidence of pain after penile augmentation in the HA group compared to the PLA group (P=0.33). In the postaugmentation penile inflammation, there was no difference (P=0.98) in the HA group compared to the PLA group. CONCLUSION: There are differences in the efficacy of penile augmentation with the superiority of HA in increasing penile diameter and postaugmentation sexual satisfaction compared to PLA. There was no difference in the incidence of complications between using HA and PLA. Lippincott Williams & Wilkins 2023-07-22 /pmc/articles/PMC10473315/ /pubmed/37663705 http://dx.doi.org/10.1097/MS9.0000000000001094 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Articles
Kusumaputra, Ahmad
Setiawan, Muhammad R.
Soebadi, Mohammad A.
Wirjopranoto, Soetojo
Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title_full Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title_fullStr Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title_full_unstemmed Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title_short Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
title_sort efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473315/
https://www.ncbi.nlm.nih.gov/pubmed/37663705
http://dx.doi.org/10.1097/MS9.0000000000001094
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