Clarithromycin-induced acute liver injury in a patient with positive Helicobacter pylori: a case report and review of the literature

INTRODUCTION AND IMPORTANCE: While 14-day triple therapy with clarithromycin is a common approach for eradicating Helicobacter pylori infection, it is essential to note that this treatment does not come without potential side effects. CASE PRESENTATION: We present the case of a 34-year-old male who...

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Detalles Bibliográficos
Autores principales: Sharma, Nava Raj, Wagle, Abhishesh, Bist, Manoj, Panthi, Bishal, Pokhrel Dahal, Ritu, Rokaya, Rajesh, Shrestha, Rayana, Pokhrel, Madalasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473337/
https://www.ncbi.nlm.nih.gov/pubmed/37663679
http://dx.doi.org/10.1097/MS9.0000000000001135
Descripción
Sumario:INTRODUCTION AND IMPORTANCE: While 14-day triple therapy with clarithromycin is a common approach for eradicating Helicobacter pylori infection, it is essential to note that this treatment does not come without potential side effects. CASE PRESENTATION: We present the case of a 34-year-old male who presented to the emergency department with severe vomiting and abdominal pain. Subsequent evaluation revealed that the patient had developed drug-induced liver injury (DILI). CLINICAL DISCUSSION: DILI can cause acute hepatocellular or cholestatic damage, and chronic injury can lead to hepatocellular, cholestatic, vascular, or neoplastic manifestations. CONCLUSION: Clinicians should exercise caution and be alert to the potential hepatotoxic effects of medications, especially when initiating triple therapy for H. pylori infection.

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