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Pulmonary alveolar microlithiasis: a rare case report from Syria
INTRODUCTION AND IMPORTANCE: This report presents a case of pulmonary alveolar microlithiasis (PAM), a rare disease characterized by dry cough, dyspnea, and chest pain. Most reported cases are from Turkey, with a frequency of 1.85 in 1 million, and there are no documented cases from Syria in the med...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473359/ https://www.ncbi.nlm.nih.gov/pubmed/37663718 http://dx.doi.org/10.1097/MS9.0000000000001060 |
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author | Batesh, Duaa Habash, Roaa Alhaffar, Mhd Nabih Almani, Imad |
author_facet | Batesh, Duaa Habash, Roaa Alhaffar, Mhd Nabih Almani, Imad |
author_sort | Batesh, Duaa |
collection | PubMed |
description | INTRODUCTION AND IMPORTANCE: This report presents a case of pulmonary alveolar microlithiasis (PAM), a rare disease characterized by dry cough, dyspnea, and chest pain. Most reported cases are from Turkey, with a frequency of 1.85 in 1 million, and there are no documented cases from Syria in the medical literature. Here, we present the first case report from Syria. CASE PRESENTATION: A 56-year-old male patient complained of a dry cough that began 4 years ago and had worsened over the last 3 months, along with a grade I dyspnea. Chest radiograph showed a ‘sandstorm-like’ appearance, and a computed tomography scan revealed diffuse ground-glass opacities. To confirm the diagnosis, we performed a transbronchial lung biopsy and bronchial washing. Histopathology results revealed interalveolar calcification consistent with PAM. The diagnosis was based on radiological and lung biopsy findings. The patient received oxygen therapy, resulting in significant improvement. We recommended the use of a home oxygen machine for episodes of shortness of breath. CLINICAL DISCUSSION: PAM is an autosomal recessive disease caused by a mutation in the SLC34A2 gene (solute carrier family 34, member 2 gene), characterized by intra-alveolar airspace microliths called calcospherites. Miliary tuberculosis should be considered a differential diagnosis. CONCLUSIONS: The disease progresses slowly and is often diagnosed incidentally. Lung transplantation remains the only effective treatment. |
format | Online Article Text |
id | pubmed-10473359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104733592023-09-02 Pulmonary alveolar microlithiasis: a rare case report from Syria Batesh, Duaa Habash, Roaa Alhaffar, Mhd Nabih Almani, Imad Ann Med Surg (Lond) Case Reports INTRODUCTION AND IMPORTANCE: This report presents a case of pulmonary alveolar microlithiasis (PAM), a rare disease characterized by dry cough, dyspnea, and chest pain. Most reported cases are from Turkey, with a frequency of 1.85 in 1 million, and there are no documented cases from Syria in the medical literature. Here, we present the first case report from Syria. CASE PRESENTATION: A 56-year-old male patient complained of a dry cough that began 4 years ago and had worsened over the last 3 months, along with a grade I dyspnea. Chest radiograph showed a ‘sandstorm-like’ appearance, and a computed tomography scan revealed diffuse ground-glass opacities. To confirm the diagnosis, we performed a transbronchial lung biopsy and bronchial washing. Histopathology results revealed interalveolar calcification consistent with PAM. The diagnosis was based on radiological and lung biopsy findings. The patient received oxygen therapy, resulting in significant improvement. We recommended the use of a home oxygen machine for episodes of shortness of breath. CLINICAL DISCUSSION: PAM is an autosomal recessive disease caused by a mutation in the SLC34A2 gene (solute carrier family 34, member 2 gene), characterized by intra-alveolar airspace microliths called calcospherites. Miliary tuberculosis should be considered a differential diagnosis. CONCLUSIONS: The disease progresses slowly and is often diagnosed incidentally. Lung transplantation remains the only effective treatment. Lippincott Williams & Wilkins 2023-07-19 /pmc/articles/PMC10473359/ /pubmed/37663718 http://dx.doi.org/10.1097/MS9.0000000000001060 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Reports Batesh, Duaa Habash, Roaa Alhaffar, Mhd Nabih Almani, Imad Pulmonary alveolar microlithiasis: a rare case report from Syria |
title | Pulmonary alveolar microlithiasis: a rare case report from Syria |
title_full | Pulmonary alveolar microlithiasis: a rare case report from Syria |
title_fullStr | Pulmonary alveolar microlithiasis: a rare case report from Syria |
title_full_unstemmed | Pulmonary alveolar microlithiasis: a rare case report from Syria |
title_short | Pulmonary alveolar microlithiasis: a rare case report from Syria |
title_sort | pulmonary alveolar microlithiasis: a rare case report from syria |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473359/ https://www.ncbi.nlm.nih.gov/pubmed/37663718 http://dx.doi.org/10.1097/MS9.0000000000001060 |
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