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TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2

OBJECTIVE: Stroke is a kind of cerebrovascular disease with high mortality. TMAO has been shown to aggravate stroke outcomes, but its mechanism remains unclear. MATERIALS AND METHODS: Mice were fed with 0.12% TMAO for 16 weeks. Then, mice were made into MCAO/R models. Neurological score, infarct vol...

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Detalles Bibliográficos
Autores principales:	Ge, Pengxin, Duan, Huijie, Tao, Chunrong, Niu, Sensen, Hu, Yiran, Duan, Rui, Shen, Aizong, Sun, Yancai, Sun, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473438/ https://www.ncbi.nlm.nih.gov/pubmed/37663757 http://dx.doi.org/10.2147/JIR.S399480

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