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CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects motor neurons in the spinal cord, brainstem and motor cortex, leading to paralysis and eventually to death within 3–5 years of symptom onset. To date, no cure or effective therapy is available. The role of chronic...
Autores principales: | De Lorenzo, Francesca, Lüningschrör, Patrick, Nam, Jinhan, Beckett, Liam, Pilotto, Federica, Galli, Emilia, Lindholm, Päivi, Rüdt von Collenberg, Cora, Mungwa, Simon Tii, Jablonka, Sibylle, Kauder, Julia, Thau-Habermann, Nadine, Petri, Susanne, Lindholm, Dan, Saxena, Smita, Sendtner, Michael, Saarma, Mart, Voutilainen, Merja H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473573/ https://www.ncbi.nlm.nih.gov/pubmed/36928391 http://dx.doi.org/10.1093/brain/awad087 |
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