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Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

Structure-guided rational immunogen design can generate optimized immunogens that elicit a desired humoral response. Design strategies often center upon targeting conserved sites on viral glycoproteins that will ultimately confer potent neutralization. For SARS-CoV-2 (SARS-2), the surface-exposed sp...

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Detalles Bibliográficos
Autores principales:	Hauser, Blake M., Sangesland, Maya, Lam, Evan C., Denis, Kerri J. St., Sheehan, Maegan L., Vu, Mya L., Cheng, Agnes H., Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473630/ https://www.ncbi.nlm.nih.gov/pubmed/37662405 http://dx.doi.org/10.1101/2023.08.21.554179

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