Age and obesity-driven changes in the extracellular matrix of the primary tumor and metastatic site influence tumor invasion and metastatic outgrowth

Younger age and obesity increase the incidence and metastasis of triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. The extracellular matrix (ECM) promotes tumor invasion and metastasis. We characterized the effect of age and obesity on the ECM of mammary fat pads, lungs,...

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Detalles Bibliográficos
Autores principales: Conner, Sydney J., Guarin, Justinne R., Borges, Hannah B., Salhany, Kenneth J., Mensah, Diamond N., Hamilton, Grace A., Le, Giang H., Oudin, Madeleine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473680/
https://www.ncbi.nlm.nih.gov/pubmed/37662270
http://dx.doi.org/10.1101/2023.08.24.554492

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