Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR

Addiction to the WRN helicase is a unique vulnerability of human cancers with high levels of microsatellite instability (MSI-H). However, while prolonged loss of WRN ultimately leads to cell death, little is known about how MSI-H cancers initially respond to acute loss of WRN, knowledge that would b...

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Detalles Bibliográficos
Autores principales: Zong, Dali, Koussa, Natasha C., Cornwell, James A., Pankajam, Ajith V., Kruhlak, Michael J., Wong, Nancy, Chari, Raj, Cappell, Steven D., Nussenzweig, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473727/
https://www.ncbi.nlm.nih.gov/pubmed/37662356
http://dx.doi.org/10.1101/2023.07.28.550976

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