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Computational Drug Design of Novel Agonists of the μ -Opioid Receptor to Inhibit Pain Signaling

Opioids such as Morphine, Codeine, Hydrocodone, and Oxycodone target the μ-opioid receptor, a G-protein-coupled receptor (GPCR), blocking the transmission of nociceptive signals. In this study, four opioids were analyzed for ADMET properties and molecular interactions with a GPCR crystal structure (...

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Detalles Bibliográficos
Autores principales:	Daoud, Nancy, Mateos, Diego Lopez, Riley, Mary A., Siegel, Justin B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473735/ https://www.ncbi.nlm.nih.gov/pubmed/37662242 http://dx.doi.org/10.1101/2023.08.25.554876

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