Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb

Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses...

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Detalles Bibliográficos
Autores principales: Walton, Sara, Fenyi, Alexis, Tittle, Tyler, Sidransky, Ellen, Pal, Gian, Choi, Solji, Melki, Ronald, Killinger, Bryan A., Kordower, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473741/
https://www.ncbi.nlm.nih.gov/pubmed/37662402
http://dx.doi.org/10.1101/2023.08.24.554646

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