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Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren’s Disease

OBJECTIVES: Inflammatory cytokines that signal through the JAK- STAT pathway, especially interferons (IFNs), are implicated in Sjögren’s Disease (SjD). Although inhibition of JAKs is effective in other autoimmune diseases, a systematic investigation of IFN-JAK-STAT signaling and effect of JAK inhibi...

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Detalles Bibliográficos
Autores principales:	Gupta, Sarthak, Yamada, Eiko, Nakamura, Hiroyuki, Perez, Paola, Pranzatelli, Thomas J.F., Dominick, Kalie, Jang, Shyh-Ing, Abed, Mehdi, Martin, Daniel, Burbelo, Peter, Zheng, Changyu, French, Ben, Alevizos, Ilias, Khavandgar, Zohreh, Beach, Margaret, Pelayo, Eileen, Walitt, Brian, Hasni, Sarfaraz, Kaplan, Mariana J., Tandon, Mayank, Teresa Magone, M., Kleiner, David E., Chiorini, John A., Baer, Alan N., Warner, Blake M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473773/ https://www.ncbi.nlm.nih.gov/pubmed/37662351 http://dx.doi.org/10.1101/2023.08.16.23294130

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