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Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hypergly...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474037/ https://www.ncbi.nlm.nih.gov/pubmed/37524865 http://dx.doi.org/10.1038/s12276-023-01043-8 |
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author | Son, Jinsook Accili, Domenico |
author_facet | Son, Jinsook Accili, Domenico |
author_sort | Son, Jinsook |
collection | PubMed |
description | The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment. |
format | Online Article Text |
id | pubmed-10474037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104740372023-09-03 Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes Son, Jinsook Accili, Domenico Exp Mol Med Review Article The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment. Nature Publishing Group UK 2023-08-01 /pmc/articles/PMC10474037/ /pubmed/37524865 http://dx.doi.org/10.1038/s12276-023-01043-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Son, Jinsook Accili, Domenico Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title_full | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title_fullStr | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title_full_unstemmed | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title_short | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
title_sort | reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474037/ https://www.ncbi.nlm.nih.gov/pubmed/37524865 http://dx.doi.org/10.1038/s12276-023-01043-8 |
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