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Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes

The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hypergly...

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Detalles Bibliográficos
Autores principales: Son, Jinsook, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474037/
https://www.ncbi.nlm.nih.gov/pubmed/37524865
http://dx.doi.org/10.1038/s12276-023-01043-8
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author Son, Jinsook
Accili, Domenico
author_facet Son, Jinsook
Accili, Domenico
author_sort Son, Jinsook
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description The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment.
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spelling pubmed-104740372023-09-03 Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes Son, Jinsook Accili, Domenico Exp Mol Med Review Article The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment. Nature Publishing Group UK 2023-08-01 /pmc/articles/PMC10474037/ /pubmed/37524865 http://dx.doi.org/10.1038/s12276-023-01043-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Son, Jinsook
Accili, Domenico
Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title_full Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title_fullStr Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title_full_unstemmed Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title_short Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
title_sort reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474037/
https://www.ncbi.nlm.nih.gov/pubmed/37524865
http://dx.doi.org/10.1038/s12276-023-01043-8
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