The non-attached biofilm aggregate

Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kragh, Kasper N., Tolker-Nielsen, Tim, Lichtenberg, Mads
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474055/
https://www.ncbi.nlm.nih.gov/pubmed/37658117
http://dx.doi.org/10.1038/s42003-023-05281-4
_version_ 1785100407296491520
author Kragh, Kasper N.
Tolker-Nielsen, Tim
Lichtenberg, Mads
author_facet Kragh, Kasper N.
Tolker-Nielsen, Tim
Lichtenberg, Mads
author_sort Kragh, Kasper N.
collection PubMed
description Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates.
format Online
Article
Text
id pubmed-10474055
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-104740552023-09-03 The non-attached biofilm aggregate Kragh, Kasper N. Tolker-Nielsen, Tim Lichtenberg, Mads Commun Biol Review Article Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates. Nature Publishing Group UK 2023-09-01 /pmc/articles/PMC10474055/ /pubmed/37658117 http://dx.doi.org/10.1038/s42003-023-05281-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kragh, Kasper N.
Tolker-Nielsen, Tim
Lichtenberg, Mads
The non-attached biofilm aggregate
title The non-attached biofilm aggregate
title_full The non-attached biofilm aggregate
title_fullStr The non-attached biofilm aggregate
title_full_unstemmed The non-attached biofilm aggregate
title_short The non-attached biofilm aggregate
title_sort non-attached biofilm aggregate
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474055/
https://www.ncbi.nlm.nih.gov/pubmed/37658117
http://dx.doi.org/10.1038/s42003-023-05281-4
work_keys_str_mv AT kraghkaspern thenonattachedbiofilmaggregate
AT tolkernielsentim thenonattachedbiofilmaggregate
AT lichtenbergmads thenonattachedbiofilmaggregate
AT kraghkaspern nonattachedbiofilmaggregate
AT tolkernielsentim nonattachedbiofilmaggregate
AT lichtenbergmads nonattachedbiofilmaggregate

Ejemplares similares