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Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially neoplastic cells, highlighting their importance in homeostasis, host defense against pathogens, cancer, and a wide range of...

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Autores principales: Lee, Ein, Song, Chang-Hyun, Bae, Sung-Jin, Ha, Ki-Tae, Karki, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474065/
https://www.ncbi.nlm.nih.gov/pubmed/37612410
http://dx.doi.org/10.1038/s12276-023-01069-y
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author Lee, Ein
Song, Chang-Hyun
Bae, Sung-Jin
Ha, Ki-Tae
Karki, Rajendra
author_facet Lee, Ein
Song, Chang-Hyun
Bae, Sung-Jin
Ha, Ki-Tae
Karki, Rajendra
author_sort Lee, Ein
collection PubMed
description Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially neoplastic cells, highlighting their importance in homeostasis, host defense against pathogens, cancer, and a wide range of other pathologies. Although these four RCD pathways employ distinct molecular and cellular processes, emerging genetic and biochemical studies have suggested remarkable flexibility and crosstalk among them. The crosstalk among pyroptosis, apoptosis and necroptosis pathways is more evident in cellular responses to infection, which has led to the conceptualization of PANoptosis. In this review, we provide a brief overview of the molecular mechanisms of pyroptosis, apoptosis, necroptosis, and ferroptosis and their importance in maintaining homeostasis. We discuss the intricate crosstalk among these RCD pathways and the current evidence supporting PANoptosis, focusing on infectious diseases and cancer. Understanding the fundamental processes of various cell death pathways is crucial to inform the development of new therapeutics against many diseases, including infection, sterile inflammation, and cancer.
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spelling pubmed-104740652023-09-03 Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis Lee, Ein Song, Chang-Hyun Bae, Sung-Jin Ha, Ki-Tae Karki, Rajendra Exp Mol Med Review Article Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially neoplastic cells, highlighting their importance in homeostasis, host defense against pathogens, cancer, and a wide range of other pathologies. Although these four RCD pathways employ distinct molecular and cellular processes, emerging genetic and biochemical studies have suggested remarkable flexibility and crosstalk among them. The crosstalk among pyroptosis, apoptosis and necroptosis pathways is more evident in cellular responses to infection, which has led to the conceptualization of PANoptosis. In this review, we provide a brief overview of the molecular mechanisms of pyroptosis, apoptosis, necroptosis, and ferroptosis and their importance in maintaining homeostasis. We discuss the intricate crosstalk among these RCD pathways and the current evidence supporting PANoptosis, focusing on infectious diseases and cancer. Understanding the fundamental processes of various cell death pathways is crucial to inform the development of new therapeutics against many diseases, including infection, sterile inflammation, and cancer. Nature Publishing Group UK 2023-08-23 /pmc/articles/PMC10474065/ /pubmed/37612410 http://dx.doi.org/10.1038/s12276-023-01069-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lee, Ein
Song, Chang-Hyun
Bae, Sung-Jin
Ha, Ki-Tae
Karki, Rajendra
Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title_full Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title_fullStr Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title_full_unstemmed Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title_short Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
title_sort regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474065/
https://www.ncbi.nlm.nih.gov/pubmed/37612410
http://dx.doi.org/10.1038/s12276-023-01069-y
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