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Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans
Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understoo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474159/ https://www.ncbi.nlm.nih.gov/pubmed/37658076 http://dx.doi.org/10.1038/s41467-023-40998-0 |
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author | Yaakub, Siti N. White, Tristan A. Roberts, Jamie Martin, Eleanor Verhagen, Lennart Stagg, Charlotte J. Hall, Stephen Fouragnan, Elsa F. |
author_facet | Yaakub, Siti N. White, Tristan A. Roberts, Jamie Martin, Eleanor Verhagen, Lennart Stagg, Charlotte J. Hall, Stephen Fouragnan, Elsa F. |
author_sort | Yaakub, Siti N. |
collection | PubMed |
description | Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions and investigated the effects of theta-burst TUS, a protocol shown to increase corticospinal excitability, on the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and functional connectivity. We show that theta-burst TUS in humans selectively reduces GABA levels in the posterior cingulate, but not the dorsal anterior cingulate cortex. Functional connectivity increased following TUS in both regions. Our findings suggest that TUS changes overall excitability by reducing GABAergic inhibition and that changes in TUS-mediated neuroplasticity last at least 50 mins after stimulation. The difference in TUS effects on the posterior and anterior cingulate could suggest state- or location-dependency of the TUS effect—both mechanisms increasingly recognized to influence the brain’s response to neuromodulation. |
format | Online Article Text |
id | pubmed-10474159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104741592023-09-03 Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans Yaakub, Siti N. White, Tristan A. Roberts, Jamie Martin, Eleanor Verhagen, Lennart Stagg, Charlotte J. Hall, Stephen Fouragnan, Elsa F. Nat Commun Article Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions and investigated the effects of theta-burst TUS, a protocol shown to increase corticospinal excitability, on the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and functional connectivity. We show that theta-burst TUS in humans selectively reduces GABA levels in the posterior cingulate, but not the dorsal anterior cingulate cortex. Functional connectivity increased following TUS in both regions. Our findings suggest that TUS changes overall excitability by reducing GABAergic inhibition and that changes in TUS-mediated neuroplasticity last at least 50 mins after stimulation. The difference in TUS effects on the posterior and anterior cingulate could suggest state- or location-dependency of the TUS effect—both mechanisms increasingly recognized to influence the brain’s response to neuromodulation. Nature Publishing Group UK 2023-09-01 /pmc/articles/PMC10474159/ /pubmed/37658076 http://dx.doi.org/10.1038/s41467-023-40998-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yaakub, Siti N. White, Tristan A. Roberts, Jamie Martin, Eleanor Verhagen, Lennart Stagg, Charlotte J. Hall, Stephen Fouragnan, Elsa F. Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title | Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title_full | Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title_fullStr | Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title_full_unstemmed | Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title_short | Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
title_sort | transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474159/ https://www.ncbi.nlm.nih.gov/pubmed/37658076 http://dx.doi.org/10.1038/s41467-023-40998-0 |
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