Cargando…

Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy

Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of the neutrophil-derived enzyme myeloperoxidase (MPO) predict o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nettersheim, Felix Sebastian, Schlüter, Johannes David, Kreuzberg, Wiebke, Mehrkens, Dennis, Grimm, Simon, Nemade, Harshal, Braumann, Simon, Hof, Alexander, Guthoff, Henning, Peters, Vera, Hoyer, Friedrich Felix, Kargapolova, Yulia, Lackmann, Jan-Wilm, Müller, Stefan, Pallasch, Christian P., Hallek, Michael, Sachinidis, Agapios, Adam, Matti, Winkels, Holger, Baldus, Stephan, Geißen, Simon, Mollenhauer, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474188/ https://www.ncbi.nlm.nih.gov/pubmed/37656254 http://dx.doi.org/10.1007/s00395-023-01006-0

Ejemplares similares

Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction
por: Guthoff, Henning, et al.
Publicado: (2022)

The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication
por: Kargapolova, Yulia, et al.
Publicado: (2021)

Myeloid leukocytes’ diverse effects on cardiovascular and systemic inflammation in chronic kidney disease
por: Hof, Alexander, et al.
Publicado: (2022)

Nitro-Oleic Acid (NO(2)-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis
por: Braumann, Simon, et al.
Publicado: (2021)

Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation
por: Mollenhauer, Martin, et al.
Publicado: (2021)

Vascular Ultrasound for In Vivo Assessment of Arterial Pathologies in a Murine Model of Atherosclerosis and Aortic Aneurysm
por: Hof, Alexander, et al.
Publicado: (2023)

Immunotherapeutic Strategies in Cancer and Atherosclerosis—Two Sides of the Same Coin
por: Nettersheim, Felix Sebastian, et al.
Publicado: (2022)

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2016)

Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
por: Mollenhauer, Martin, et al.
Publicado: (2020)

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
por: Nemade, Harshal, et al.
Publicado: (2018)

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
por: Chaudhari, Umesh, et al.
Publicado: (2015)

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
por: Srinivasan, Sureshkumar Perumal, et al.
Publicado: (2022)

Is there a benefit of ICD treatment in patients with persistent severely reduced systolic left ventricular function after TAVI?
por: Nies, Richard J., et al.
Publicado: (2021)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Live-Cell Imaging of the Contractile Velocity and Transient Intracellular Ca(2+) Fluctuations in Human Stem Cell-Derived Cardiomyocytes
por: Acharya, Aviseka, et al.
Publicado: (2022)

Correction: Nemade, H.; et al. Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells. Cells 2020, 9, 554
por: Nemade, Harshal, et al.
Publicado: (2020)

Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells
por: Nemade, Harshal, et al.
Publicado: (2020)

Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes
por: Acharya, Aviseka, et al.
Publicado: (2022)

Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B
por: Nettersheim, Felix Sebastian, et al.
Publicado: (2022)

Significance of myeloperoxidase plasma levels as a predictor for cardiac resynchronization therapy response
por: Sultan, A., et al.
Publicado: (2020)

Highlight report: Cardiotoxicity screening
por: Sachinidis, Agapios
Publicado: (2016)

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs
por: Sachinidis, Agapios
Publicado: (2020)

High-throughput base editing: a promising technology for precision medicine and drug discovery
por: Sachinidis, Agapios
Publicado: (2021)

Vaccination in Atherosclerosis
por: Nettersheim, Felix Sebastian, et al.
Publicado: (2020)

Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages
por: Peinkofer, Gabriel, et al.
Publicado: (2021)

Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications
por: Doss, Michael Xavier, et al.
Publicado: (2019)

Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs
por: Papazoglou, Panagiota, et al.
Publicado: (2021)

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation
por: Kremserova, Silvie, et al.
Publicado: (2016)

Myeloperoxidase deficiency preserves vasomotor function in humans
por: Rudolph, Tanja K., et al.
Publicado: (2012)

Detection of Novel Potential Regulators of Stem Cell Differentiation and Cardiogenesis through Combined Genome-Wide Profiling of Protein-Coding Transcripts and microRNAs
por: Machado, Rui, et al.
Publicado: (2021)

Novel Anthracycline Utorubicin for Cancer Therapy
por: Simón‐Gracia, Lorena, et al.
Publicado: (2021)

Cardiovascular genomics: A current overview of in vivo and in vitro studies
por: Mariappan, Devi, et al.
Publicado: (2006)

Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase
por: Gamon, Luke F., et al.
Publicado: (2019)

Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now
por: Simeon, Michael, et al.
Publicado: (2021)

Myeloperoxidase in Health and Disease
por: Ortiz-Cerda, Tamara, et al.
Publicado: (2023)

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines
por: Edwardson, Derek W., et al.
Publicado: (2015)

Experimentally Induced Anti-Myeloperoxidase Vasculitis Is Not Attenuated in Factor B or VISTA Deficient Mice
por: Flórez-Barrós, Fernanda, et al.
Publicado: (2021)

A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase
por: Buchan, Kyle D., et al.
Publicado: (2019)

Resonant Frequency Characteristics of a SAW Device Attached to Resonating Micropillars
por: Ramakrishnan, N., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_dtttgeel239srgkhpng127fv16