α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this interaction in normal and failing hearts remains unknown. Lactate is a crucial energy substrate of the heart. Here, we identify that α-MHC unde...

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Detalles Bibliográficos
Autores principales: Zhang, Naijin, Zhang, Ying, Xu, Jiaqi, Wang, Pengbo, Wu, Boquan, Lu, Saien, Lu, Xinxin, You, Shilong, Huang, Xinyue, Li, Mohan, Zou, Yuanming, Liu, Mengke, Zhao, Yuanhui, Sun, Guozhe, Wang, Wenbin, Geng, Danxi, Liu, Jingwei, Cao, Liu, Sun, Yingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474270/
https://www.ncbi.nlm.nih.gov/pubmed/37443257
http://dx.doi.org/10.1038/s41422-023-00844-w

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