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IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m(6)A-dependent manner

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer (CRC) oncogenesis, progression, and drug resistance remain unclear. This study found that I...

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Detalles Bibliográficos
Autores principales:	Chen, Li-Jie, Liu, Hui-Ye, Xiao, Zhi-Yuan, Qiu, Ting, Zhang, Dan, Zhang, Ling-Jie, Han, Fang-Yi, Chen, Guo-Jun, Xu, Xue-Mei, Zhu, Jiong-Hua, Ding, Yan-Qing, Wang, Shu-Yang, Ye, Ya-Ping, Jiao, Hong-Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474290/ https://www.ncbi.nlm.nih.gov/pubmed/37658049 http://dx.doi.org/10.1038/s41419-023-06099-y

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