LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation

Wnt/β-catenin signaling plays a crucial role in cancer development, primarily activated by β-catenin forming a transcription complex with LEF/TCF in the nucleus and initiating the transcription of Wnt target genes. Here, we report that LEF1, a member of the LEF/TCF family, can form intrinsically dis...

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Detalles Bibliográficos
Autores principales: Zhao, Bing, Li, Zhuoxin, Yu, Shaoqing, Li, Tingting, Wang, Wen, Liu, Ran, Zhang, Biyu, Fang, Xiya, Shen, Yezhuang, Han, Qiuying, Xu, Xin, Wang, Kai, Gong, Weili, Li, Tao, Li, Ailing, Zhou, Tao, Li, Weihua, Li, Teng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474303/
https://www.ncbi.nlm.nih.gov/pubmed/37657935
http://dx.doi.org/10.26508/lsa.202302118

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