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Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives

We outline essential considerations for any study of partial randomisation of research funding, and consider scenarios in which randomised controlled trials (RCTs) would be feasible and appropriate. We highlight the interdependence of target outcomes, sample availability and statistical power for de...

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Autores principales: Stafford, Tom, Rombach, Ines, Hind, Dan, Mateen, Bilal, Woods, Helen Buckley, Dimario, Munya, Wilsdon, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474338/
https://www.ncbi.nlm.nih.gov/pubmed/37663796
http://dx.doi.org/10.12688/wellcomeopenres.19565.1
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author Stafford, Tom
Rombach, Ines
Hind, Dan
Mateen, Bilal
Woods, Helen Buckley
Dimario, Munya
Wilsdon, James
author_facet Stafford, Tom
Rombach, Ines
Hind, Dan
Mateen, Bilal
Woods, Helen Buckley
Dimario, Munya
Wilsdon, James
author_sort Stafford, Tom
collection PubMed
description We outline essential considerations for any study of partial randomisation of research funding, and consider scenarios in which randomised controlled trials (RCTs) would be feasible and appropriate. We highlight the interdependence of target outcomes, sample availability and statistical power for determining the cost and feasibility of a trial. For many choices of target outcome, RCTs may be less practical and more expensive than they at first appear (in large part due to issues pertaining to sample size and statistical power). As such, we briefly discuss alternatives to RCTs. It is worth noting that many of the considerations relevant to experiments on partial randomisation may also apply to other potential experiments on funding processes (as described in The Experimental Research Funder’s Handbook. RoRI, June 2022).
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spelling pubmed-104743382023-09-03 Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives Stafford, Tom Rombach, Ines Hind, Dan Mateen, Bilal Woods, Helen Buckley Dimario, Munya Wilsdon, James Wellcome Open Res Review We outline essential considerations for any study of partial randomisation of research funding, and consider scenarios in which randomised controlled trials (RCTs) would be feasible and appropriate. We highlight the interdependence of target outcomes, sample availability and statistical power for determining the cost and feasibility of a trial. For many choices of target outcome, RCTs may be less practical and more expensive than they at first appear (in large part due to issues pertaining to sample size and statistical power). As such, we briefly discuss alternatives to RCTs. It is worth noting that many of the considerations relevant to experiments on partial randomisation may also apply to other potential experiments on funding processes (as described in The Experimental Research Funder’s Handbook. RoRI, June 2022). F1000 Research Limited 2023-07-17 /pmc/articles/PMC10474338/ /pubmed/37663796 http://dx.doi.org/10.12688/wellcomeopenres.19565.1 Text en Copyright: © 2023 Stafford T et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Stafford, Tom
Rombach, Ines
Hind, Dan
Mateen, Bilal
Woods, Helen Buckley
Dimario, Munya
Wilsdon, James
Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title_full Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title_fullStr Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title_full_unstemmed Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title_short Where next for partial randomisation of research funding? The feasibility of RCTs and alternatives
title_sort where next for partial randomisation of research funding? the feasibility of rcts and alternatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474338/
https://www.ncbi.nlm.nih.gov/pubmed/37663796
http://dx.doi.org/10.12688/wellcomeopenres.19565.1
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