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Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development
As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progre...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474436/ https://www.ncbi.nlm.nih.gov/pubmed/37662730 http://dx.doi.org/10.1016/j.heliyon.2023.e19296 |
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author | Tan, Siyuan Tang, Haodong Wang, Yang Xie, Peng Li, Haifeng Zhang, Zheng Zhou, Jiahua |
author_facet | Tan, Siyuan Tang, Haodong Wang, Yang Xie, Peng Li, Haifeng Zhang, Zheng Zhou, Jiahua |
author_sort | Tan, Siyuan |
collection | PubMed |
description | As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progression. In particular, exosomes secreted by tumor cells can change the function of surrounding cells, creating a microenvironment conducive to tumor growth and metastasis. For example, after macrophages phagocytose exosomes and accept their cargos, they activate macrophage polarization-related signaling pathways and polarize macrophages into M1 or M2 types to exert antitumor or protumor functions. Currently, the study of exosomes affecting the polarization of macrophages has attracted increasing attention. Therefore, this paper reviews relevant studies in this field to better understand the mechanism of exosome-induced macrophage polarization and provide evidence for exploring novel targets for tumor therapy and new diagnostic markers in the future. |
format | Online Article Text |
id | pubmed-10474436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104744362023-09-03 Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development Tan, Siyuan Tang, Haodong Wang, Yang Xie, Peng Li, Haifeng Zhang, Zheng Zhou, Jiahua Heliyon Review Article As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progression. In particular, exosomes secreted by tumor cells can change the function of surrounding cells, creating a microenvironment conducive to tumor growth and metastasis. For example, after macrophages phagocytose exosomes and accept their cargos, they activate macrophage polarization-related signaling pathways and polarize macrophages into M1 or M2 types to exert antitumor or protumor functions. Currently, the study of exosomes affecting the polarization of macrophages has attracted increasing attention. Therefore, this paper reviews relevant studies in this field to better understand the mechanism of exosome-induced macrophage polarization and provide evidence for exploring novel targets for tumor therapy and new diagnostic markers in the future. Elsevier 2023-08-22 /pmc/articles/PMC10474436/ /pubmed/37662730 http://dx.doi.org/10.1016/j.heliyon.2023.e19296 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Tan, Siyuan Tang, Haodong Wang, Yang Xie, Peng Li, Haifeng Zhang, Zheng Zhou, Jiahua Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title_full | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title_fullStr | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title_full_unstemmed | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title_short | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
title_sort | tumor cell-derived exosomes regulate macrophage polarization: emerging directions in the study of tumor genesis and development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474436/ https://www.ncbi.nlm.nih.gov/pubmed/37662730 http://dx.doi.org/10.1016/j.heliyon.2023.e19296 |
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