Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity

SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified...

Descripción completa

Detalles Bibliográficos
Autores principales: Olliff, Nathaniel S., Hunt, Miles A., Paudel, Sunita S., Nguyen, Kevin N., Delcher, Haley A., DeMeis, Jeffrey D., Roberts, Justin T., Fouty, Brian W., Audia, Jonathon P., Kim, Jin H., Borchert, Glen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474479/
https://www.ncbi.nlm.nih.gov/pubmed/37662051
http://dx.doi.org/10.17912/micropub.biology.000925
Descripción
Sumario:SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified these based on clinical outcomes, and sequenced their circulating sncRNAs. Excitingly, we found YRNA HY4 displays significant differential expression (p=0.025) between patients experiencing mild and severe disease. In agreement with recent reports identifying plasma YRNAs as indicators of influenza infection severity, our results strongly suggest that circulating HY4 levels represent a powerful prognostic indicator of likely SARS-CoV-2 patient infection outcome.

Ejemplares similares