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Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS

We reported a gastric anti-ulcerogenic effect of the Nigella sativa (L.)-derived herbal melanin (HM) using rat models. However, the molecular mechanisms underlying this HM gastroprotective effect remain unknown. Cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E2 (PGE2) and toll-like receptor 4 (TLR...

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Detalles Bibliográficos
Autores principales:	El-Obeid, Adila, Maashi, Yahya, AlRoshody, Rehab, Alatar, Ghada, Aljudayi, Modhi, Al-Eidi, Hamad, AlGaith, Nouf, Khan, Altaf Husain, Hassib, Adil, Matou-Nasri, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474668/ https://www.ncbi.nlm.nih.gov/pubmed/37658354 http://dx.doi.org/10.1186/s12906-023-04124-3

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