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Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis

This meta-analysis was conducted to assess the effectiveness of topical anesthetics in preventing premature ejaculation. We conducted an online database search for original studies comparing topical anesthetic agents with placebo in patients with premature ejaculation. After selecting relevant artic...

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Detalles Bibliográficos
Autores principales: Shah, M Danial Ali, Shah, Safdar, Nusrat, Nadeem Bin, Zafar, Nauman, Rehman, Assad Ur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474909/
https://www.ncbi.nlm.nih.gov/pubmed/37664322
http://dx.doi.org/10.7759/cureus.42913
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author Shah, M Danial Ali
Shah, Safdar
Nusrat, Nadeem Bin
Zafar, Nauman
Rehman, Assad Ur
author_facet Shah, M Danial Ali
Shah, Safdar
Nusrat, Nadeem Bin
Zafar, Nauman
Rehman, Assad Ur
author_sort Shah, M Danial Ali
collection PubMed
description This meta-analysis was conducted to assess the effectiveness of topical anesthetics in preventing premature ejaculation. We conducted an online database search for original studies comparing topical anesthetic agents with placebo in patients with premature ejaculation. After selecting relevant articles, we extracted data on baseline characteristics and predetermined endpoints. Intravaginal ejaculatory latency time (IELT) was the primary outcome for efficacy. Mean differences and corresponding 95% confidence intervals were used to present continuous data. A random-effects model was used to pool the data, and subgroup analysis was performed based on the type of anesthetic agent used. Eleven randomized controlled trials were examined, involving a total of 2008 participants. After analyzing the combined results, it was found that Severance Secret (SS) cream (CJ CheilJedang Corporation, Seoul, South Korea) demonstrated significantly higher effectiveness than a placebo in increasing IELT (P = 0.001). Similarly, the topical eutectic mixture for premature ejaculation (TEMPE), lidocaine, and the eutectic mixture of local anesthetics (EMLA) were significantly more efficient than a placebo (P<0.00001; P = 0.0001; P<0.00001). Additionally, it was found that lidocaine gel was more efficient than paroxetine or sildenafil (P = 0.04; P<0.00001). In conclusion, topical anesthetics increase IELT in men with premature ejaculation more effectively than placebo, sildenafil, tadalafil, paroxetine, and dapoxetine.
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spelling pubmed-104749092023-09-03 Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis Shah, M Danial Ali Shah, Safdar Nusrat, Nadeem Bin Zafar, Nauman Rehman, Assad Ur Cureus Internal Medicine This meta-analysis was conducted to assess the effectiveness of topical anesthetics in preventing premature ejaculation. We conducted an online database search for original studies comparing topical anesthetic agents with placebo in patients with premature ejaculation. After selecting relevant articles, we extracted data on baseline characteristics and predetermined endpoints. Intravaginal ejaculatory latency time (IELT) was the primary outcome for efficacy. Mean differences and corresponding 95% confidence intervals were used to present continuous data. A random-effects model was used to pool the data, and subgroup analysis was performed based on the type of anesthetic agent used. Eleven randomized controlled trials were examined, involving a total of 2008 participants. After analyzing the combined results, it was found that Severance Secret (SS) cream (CJ CheilJedang Corporation, Seoul, South Korea) demonstrated significantly higher effectiveness than a placebo in increasing IELT (P = 0.001). Similarly, the topical eutectic mixture for premature ejaculation (TEMPE), lidocaine, and the eutectic mixture of local anesthetics (EMLA) were significantly more efficient than a placebo (P<0.00001; P = 0.0001; P<0.00001). Additionally, it was found that lidocaine gel was more efficient than paroxetine or sildenafil (P = 0.04; P<0.00001). In conclusion, topical anesthetics increase IELT in men with premature ejaculation more effectively than placebo, sildenafil, tadalafil, paroxetine, and dapoxetine. Cureus 2023-08-03 /pmc/articles/PMC10474909/ /pubmed/37664322 http://dx.doi.org/10.7759/cureus.42913 Text en Copyright © 2023, Shah et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Shah, M Danial Ali
Shah, Safdar
Nusrat, Nadeem Bin
Zafar, Nauman
Rehman, Assad Ur
Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title_full Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title_fullStr Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title_full_unstemmed Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title_short Topical Anesthetics and Premature Ejaculation: A Systematic Review and Meta-Analysis
title_sort topical anesthetics and premature ejaculation: a systematic review and meta-analysis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474909/
https://www.ncbi.nlm.nih.gov/pubmed/37664322
http://dx.doi.org/10.7759/cureus.42913
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