RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1

RNA binding proteins have the critical role in renal cell carcinoma (RCC) progression. However, the role of RBM47 in RCC has not been elucidated. In this study, we found that RBM47 was downregulated in RCC tissues and its expression was negatively correlated with the prognosis of RCC patients. Also,...

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Autores principales: Su, Qingfu, Pan, Zhenliang, Chen, Heyi, Chen, Jiabi, Zhang, Yanmei, Zhuang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475063/
https://www.ncbi.nlm.nih.gov/pubmed/37660095
http://dx.doi.org/10.1038/s41420-023-01623-7
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author Su, Qingfu
Pan, Zhenliang
Chen, Heyi
Chen, Jiabi
Zhang, Yanmei
Zhuang, Wei
author_facet Su, Qingfu
Pan, Zhenliang
Chen, Heyi
Chen, Jiabi
Zhang, Yanmei
Zhuang, Wei
author_sort Su, Qingfu
collection PubMed
description RNA binding proteins have the critical role in renal cell carcinoma (RCC) progression. However, the role of RBM47 in RCC has not been elucidated. In this study, we found that RBM47 was downregulated in RCC tissues and its expression was negatively correlated with the prognosis of RCC patients. Also, we found that the expression of RBM47 was regulated by CBP/P300-mediated H3K27ac in RCC. Functionally, RBM47 restrained RCC cells proliferation and metastasis. Mechanistically, RBM47 interfered with the interaction between HOXB-AS1 and p53 proteins via directly binding with HOXB-AS1, finally promoted the entry of p53 into the nucleus and therefore activated the p53 signaling. Moreover, RBM47 had a synergistic anticancer effect with sunitinib both in vivo and in vitro. [Image: see text]
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spelling pubmed-104750632023-09-04 RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1 Su, Qingfu Pan, Zhenliang Chen, Heyi Chen, Jiabi Zhang, Yanmei Zhuang, Wei Cell Death Discov Article RNA binding proteins have the critical role in renal cell carcinoma (RCC) progression. However, the role of RBM47 in RCC has not been elucidated. In this study, we found that RBM47 was downregulated in RCC tissues and its expression was negatively correlated with the prognosis of RCC patients. Also, we found that the expression of RBM47 was regulated by CBP/P300-mediated H3K27ac in RCC. Functionally, RBM47 restrained RCC cells proliferation and metastasis. Mechanistically, RBM47 interfered with the interaction between HOXB-AS1 and p53 proteins via directly binding with HOXB-AS1, finally promoted the entry of p53 into the nucleus and therefore activated the p53 signaling. Moreover, RBM47 had a synergistic anticancer effect with sunitinib both in vivo and in vitro. [Image: see text] Nature Publishing Group UK 2023-09-02 /pmc/articles/PMC10475063/ /pubmed/37660095 http://dx.doi.org/10.1038/s41420-023-01623-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Su, Qingfu
Pan, Zhenliang
Chen, Heyi
Chen, Jiabi
Zhang, Yanmei
Zhuang, Wei
RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title_full RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title_fullStr RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title_full_unstemmed RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title_short RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1
title_sort rbm47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncrna hoxb-as1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475063/
https://www.ncbi.nlm.nih.gov/pubmed/37660095
http://dx.doi.org/10.1038/s41420-023-01623-7
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