Recombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors

The efficacy of chimeric antigen receptor T (CAR-T) cells for solid tumors remains unsatisfactory due to the limited tumor infiltration and immunosuppressive microenvironment. To overcome these limitations, the genetically engineered recombinant oncolytic adenoviruses (OAVs) that conditionally repli...

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Detalles Bibliográficos
Autores principales: Fang, Lin, Yuan, Sen, Wang, Meng, Zhang, Chen, Wang, Xueyan, Li, Hailong, Yang, Jie, Li, Wanjing, Sun, Nan, Zhang, Qi, Zhang, Yuxin, Chai, Dafei, Li, Huizhong, Zheng, Junnian, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475122/
https://www.ncbi.nlm.nih.gov/pubmed/37660142
http://dx.doi.org/10.1038/s41420-023-01626-4

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