Prediction of base editor off-targets by deep learning

Due to the tolerance of mismatches between gRNA and targeting sequence, base editors frequently induce unwanted Cas9-dependent off-target mutations. Here, to develop models to predict such off-targets, we design gRNA-off- target pairs for adenine base editors (ABEs) and cytosine base editors (CBEs)...

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Detalles Bibliográficos
Autores principales: Zhang, Chengdong, Yang, Yuan, Qi, Tao, Zhang, Yuening, Hou, Linghui, Wei, Jingjing, Yang, Jingcheng, Shi, Leming, Ong, Sang-Ging, Wang, Hongyan, Wang, Hui, Yu, Bo, Wang, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475126/
https://www.ncbi.nlm.nih.gov/pubmed/37660097
http://dx.doi.org/10.1038/s41467-023-41004-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475126/
https://www.ncbi.nlm.nih.gov/pubmed/37660097
http://dx.doi.org/10.1038/s41467-023-41004-3

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