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Clozapine-induced eosinophilia: A case report

Schizophrenia is a chronic neuropsychiatric illness defined by the appearance of positive, and negative symptoms and/or cognitive impairment. Antipsychotic drugs are predominantly used in the treatment of psychotic disorders, but not all patients with schizophrenia respond to every antipsychotic med...

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Autores principales: Das, Soumitra, Itrat, Annie, Hernandez, Mary Elizabeth Trejo, Subedi, Rasish, Jogarajah, Thusanth, Vashist, Sreshatha, Daggala, Nikitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475262/
https://www.ncbi.nlm.nih.gov/pubmed/37667744
http://dx.doi.org/10.1177/2050313X231195961
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author Das, Soumitra
Itrat, Annie
Hernandez, Mary Elizabeth Trejo
Subedi, Rasish
Jogarajah, Thusanth
Vashist, Sreshatha
Daggala, Nikitha
author_facet Das, Soumitra
Itrat, Annie
Hernandez, Mary Elizabeth Trejo
Subedi, Rasish
Jogarajah, Thusanth
Vashist, Sreshatha
Daggala, Nikitha
author_sort Das, Soumitra
collection PubMed
description Schizophrenia is a chronic neuropsychiatric illness defined by the appearance of positive, and negative symptoms and/or cognitive impairment. Antipsychotic drugs are predominantly used in the treatment of psychotic disorders, but not all patients with schizophrenia respond to every antipsychotic medication. Clozapine is one of the best atypical antipsychotics and is highly effective in treating treatment-resistant schizophrenia. Evidence suggests that clozapine appears to be effective in lowering the risk of suicide, extrapyramidal side effects, and relapse in patients with schizophrenia. Per contra, clozapine is not the first-line treatment due to its unalterable aftereffects such as agranulocytosis, metabolic syndrome, seizures, and rarely, eosinophilia. Eosinophilia can be life-threatening. Eosinophils infiltrate different tissues and cause inflammation in multiple organs causing end-organ damage. The current study aimed to report the incidence of eosinophilia associated with clozapine use in patients with schizophrenia. Literature on clozapine-induced eosinophilia is relatively scarce. Understanding the progression and management of clozapine-induced eosinophilia and its end-organ effects is imperative. While there is insufficient data about the guidelines in the management of clozapine-induced eosinophilia, this study contributes to understanding the patterns of the disease progression with clozapine dosage. A case study was done on a patient with schizophrenia and autistic spectrum disorder who was on clozapine. Data on how eosinophil levels varied with clozapine dosing was analyzed and documented. The evidence of clozapine dosage affecting eosinophil and C-reactive protein levels in this patient was summarized in a table and a narrative review.
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spelling pubmed-104752622023-09-04 Clozapine-induced eosinophilia: A case report Das, Soumitra Itrat, Annie Hernandez, Mary Elizabeth Trejo Subedi, Rasish Jogarajah, Thusanth Vashist, Sreshatha Daggala, Nikitha SAGE Open Med Case Rep Case Report Schizophrenia is a chronic neuropsychiatric illness defined by the appearance of positive, and negative symptoms and/or cognitive impairment. Antipsychotic drugs are predominantly used in the treatment of psychotic disorders, but not all patients with schizophrenia respond to every antipsychotic medication. Clozapine is one of the best atypical antipsychotics and is highly effective in treating treatment-resistant schizophrenia. Evidence suggests that clozapine appears to be effective in lowering the risk of suicide, extrapyramidal side effects, and relapse in patients with schizophrenia. Per contra, clozapine is not the first-line treatment due to its unalterable aftereffects such as agranulocytosis, metabolic syndrome, seizures, and rarely, eosinophilia. Eosinophilia can be life-threatening. Eosinophils infiltrate different tissues and cause inflammation in multiple organs causing end-organ damage. The current study aimed to report the incidence of eosinophilia associated with clozapine use in patients with schizophrenia. Literature on clozapine-induced eosinophilia is relatively scarce. Understanding the progression and management of clozapine-induced eosinophilia and its end-organ effects is imperative. While there is insufficient data about the guidelines in the management of clozapine-induced eosinophilia, this study contributes to understanding the patterns of the disease progression with clozapine dosage. A case study was done on a patient with schizophrenia and autistic spectrum disorder who was on clozapine. Data on how eosinophil levels varied with clozapine dosing was analyzed and documented. The evidence of clozapine dosage affecting eosinophil and C-reactive protein levels in this patient was summarized in a table and a narrative review. SAGE Publications 2023-08-31 /pmc/articles/PMC10475262/ /pubmed/37667744 http://dx.doi.org/10.1177/2050313X231195961 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Das, Soumitra
Itrat, Annie
Hernandez, Mary Elizabeth Trejo
Subedi, Rasish
Jogarajah, Thusanth
Vashist, Sreshatha
Daggala, Nikitha
Clozapine-induced eosinophilia: A case report
title Clozapine-induced eosinophilia: A case report
title_full Clozapine-induced eosinophilia: A case report
title_fullStr Clozapine-induced eosinophilia: A case report
title_full_unstemmed Clozapine-induced eosinophilia: A case report
title_short Clozapine-induced eosinophilia: A case report
title_sort clozapine-induced eosinophilia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475262/
https://www.ncbi.nlm.nih.gov/pubmed/37667744
http://dx.doi.org/10.1177/2050313X231195961
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