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Coenzyme Q10 Stimulate Reproductive Vatality
Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achiev...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475284/ https://www.ncbi.nlm.nih.gov/pubmed/37667786 http://dx.doi.org/10.2147/DDDT.S386974 |
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author | Nie, Xinyu Dong, Xinru Hu, Yuge Xu, Fangjun Hu, Cong Shu, Chang |
author_facet | Nie, Xinyu Dong, Xinru Hu, Yuge Xu, Fangjun Hu, Cong Shu, Chang |
author_sort | Nie, Xinyu |
collection | PubMed |
description | Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achieve pregnancy with current treatment, which are urgent clinical issues need to be addressed. Coenzyme Q10 (CoQ10) is a lipid-soluble electron carrier in the mitochondrial electron transport chain. It is not only essential for the mitochondria to produce energy, but also function as an antioxidant to maintain redox homeostasis in the body. Recently, the capacity of CoQ10 to reduce oxidative stress (OS), enhance mitochondrial activity, regulate gene expression and inhibit inflammatory responses, has been discovered as a novel adjuvant in male reproductive performance enhancing in both animal and human studies. Furthermore, CoQ10 is also proved to regulate immune balance, antioxidant, promote glucose and lipid metabolism. These properties will bring highlight for ovarian dysfunction reversing, ovulation ameliorating, oocyte maturation/fertilization promoting, and embryonic development optimizing. In this review, we systematically discuss the pleiotropic effects of CoQ10 in female reproductive disorders to investigate the mechanism and therapeutic potential to provide a reference in subsequent studies. |
format | Online Article Text |
id | pubmed-10475284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104752842023-09-04 Coenzyme Q10 Stimulate Reproductive Vatality Nie, Xinyu Dong, Xinru Hu, Yuge Xu, Fangjun Hu, Cong Shu, Chang Drug Des Devel Ther Review Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achieve pregnancy with current treatment, which are urgent clinical issues need to be addressed. Coenzyme Q10 (CoQ10) is a lipid-soluble electron carrier in the mitochondrial electron transport chain. It is not only essential for the mitochondria to produce energy, but also function as an antioxidant to maintain redox homeostasis in the body. Recently, the capacity of CoQ10 to reduce oxidative stress (OS), enhance mitochondrial activity, regulate gene expression and inhibit inflammatory responses, has been discovered as a novel adjuvant in male reproductive performance enhancing in both animal and human studies. Furthermore, CoQ10 is also proved to regulate immune balance, antioxidant, promote glucose and lipid metabolism. These properties will bring highlight for ovarian dysfunction reversing, ovulation ameliorating, oocyte maturation/fertilization promoting, and embryonic development optimizing. In this review, we systematically discuss the pleiotropic effects of CoQ10 in female reproductive disorders to investigate the mechanism and therapeutic potential to provide a reference in subsequent studies. Dove 2023-08-30 /pmc/articles/PMC10475284/ /pubmed/37667786 http://dx.doi.org/10.2147/DDDT.S386974 Text en © 2023 Nie et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Nie, Xinyu Dong, Xinru Hu, Yuge Xu, Fangjun Hu, Cong Shu, Chang Coenzyme Q10 Stimulate Reproductive Vatality |
title | Coenzyme Q10 Stimulate Reproductive Vatality |
title_full | Coenzyme Q10 Stimulate Reproductive Vatality |
title_fullStr | Coenzyme Q10 Stimulate Reproductive Vatality |
title_full_unstemmed | Coenzyme Q10 Stimulate Reproductive Vatality |
title_short | Coenzyme Q10 Stimulate Reproductive Vatality |
title_sort | coenzyme q10 stimulate reproductive vatality |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475284/ https://www.ncbi.nlm.nih.gov/pubmed/37667786 http://dx.doi.org/10.2147/DDDT.S386974 |
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