Cargando…

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as r...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, He, Pan, Zhenxiang, Lai, Bingjie, Zan, Chunfang, Liu, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475288/
https://www.ncbi.nlm.nih.gov/pubmed/37667787
http://dx.doi.org/10.2147/DDDT.S417051
_version_ 1785100693438201856
author Ma, He
Pan, Zhenxiang
Lai, Bingjie
Zan, Chunfang
Liu, He
author_facet Ma, He
Pan, Zhenxiang
Lai, Bingjie
Zan, Chunfang
Liu, He
author_sort Ma, He
collection PubMed
description From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for individual local anesthetic agents can support to achieve more efficient drug release and prolonged duration of action with reduced systemic toxicity. Different types of DDSs involving various carriers have been examined, including micromaterials, nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery approaches have significantly developed in the last decade due to the low systemic toxicity and the greater efficacy of non-conventional local anesthetics. Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. Recent original research utilizing nanotechnology-based delivery systems is particularly discussed, and the progress and strengths of these DDSs are highlighted. A specific focus of this review is the comparison of various nano-based DDSs for local anesthetics, which can offer additional indications for their further improvement. All in all, nano-based DDSs with unique advantages provide a novel direction for the development of safer and more effective local anesthetic formulations.
format Online
Article
Text
id pubmed-10475288
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-104752882023-09-04 Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics Ma, He Pan, Zhenxiang Lai, Bingjie Zan, Chunfang Liu, He Drug Des Devel Ther Review From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for individual local anesthetic agents can support to achieve more efficient drug release and prolonged duration of action with reduced systemic toxicity. Different types of DDSs involving various carriers have been examined, including micromaterials, nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery approaches have significantly developed in the last decade due to the low systemic toxicity and the greater efficacy of non-conventional local anesthetics. Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. Recent original research utilizing nanotechnology-based delivery systems is particularly discussed, and the progress and strengths of these DDSs are highlighted. A specific focus of this review is the comparison of various nano-based DDSs for local anesthetics, which can offer additional indications for their further improvement. All in all, nano-based DDSs with unique advantages provide a novel direction for the development of safer and more effective local anesthetic formulations. Dove 2023-08-30 /pmc/articles/PMC10475288/ /pubmed/37667787 http://dx.doi.org/10.2147/DDDT.S417051 Text en © 2023 Ma et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Ma, He
Pan, Zhenxiang
Lai, Bingjie
Zan, Chunfang
Liu, He
Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title_full Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title_fullStr Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title_full_unstemmed Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title_short Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
title_sort recent research advances in nano-based drug delivery systems for local anesthetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475288/
https://www.ncbi.nlm.nih.gov/pubmed/37667787
http://dx.doi.org/10.2147/DDDT.S417051
work_keys_str_mv AT mahe recentresearchadvancesinnanobaseddrugdeliverysystemsforlocalanesthetics
AT panzhenxiang recentresearchadvancesinnanobaseddrugdeliverysystemsforlocalanesthetics
AT laibingjie recentresearchadvancesinnanobaseddrugdeliverysystemsforlocalanesthetics
AT zanchunfang recentresearchadvancesinnanobaseddrugdeliverysystemsforlocalanesthetics
AT liuhe recentresearchadvancesinnanobaseddrugdeliverysystemsforlocalanesthetics