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Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, howe...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475355/ https://www.ncbi.nlm.nih.gov/pubmed/37670975 http://dx.doi.org/10.7150/jca.85260 |
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author | Goh, Khang Wen Stephen, Annatasha Wu, Yuan Seng Sim, Maw Shin Batumalaie, Kalaivani Gopinath, Subash C.B. Guad, Rhanye Mac Kumar, Ashok Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Velaga, Appalaraju Sarker, Md. Moklesur Rahman |
author_facet | Goh, Khang Wen Stephen, Annatasha Wu, Yuan Seng Sim, Maw Shin Batumalaie, Kalaivani Gopinath, Subash C.B. Guad, Rhanye Mac Kumar, Ashok Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Velaga, Appalaraju Sarker, Md. Moklesur Rahman |
author_sort | Goh, Khang Wen |
collection | PubMed |
description | Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers' generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications. |
format | Online Article Text |
id | pubmed-10475355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-104753552023-09-05 Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms Goh, Khang Wen Stephen, Annatasha Wu, Yuan Seng Sim, Maw Shin Batumalaie, Kalaivani Gopinath, Subash C.B. Guad, Rhanye Mac Kumar, Ashok Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Velaga, Appalaraju Sarker, Md. Moklesur Rahman J Cancer Review Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers' generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications. Ivyspring International Publisher 2023-08-06 /pmc/articles/PMC10475355/ /pubmed/37670975 http://dx.doi.org/10.7150/jca.85260 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Goh, Khang Wen Stephen, Annatasha Wu, Yuan Seng Sim, Maw Shin Batumalaie, Kalaivani Gopinath, Subash C.B. Guad, Rhanye Mac Kumar, Ashok Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Velaga, Appalaraju Sarker, Md. Moklesur Rahman Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title_full | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title_fullStr | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title_full_unstemmed | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title_short | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
title_sort | molecular targets of aptamers in gastrointestinal cancers: cancer detection, therapeutic applications, and associated mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475355/ https://www.ncbi.nlm.nih.gov/pubmed/37670975 http://dx.doi.org/10.7150/jca.85260 |
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