Cargando…

Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms

Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, howe...

Descripción completa

Detalles Bibliográficos
Autores principales: Goh, Khang Wen, Stephen, Annatasha, Wu, Yuan Seng, Sim, Maw Shin, Batumalaie, Kalaivani, Gopinath, Subash C.B., Guad, Rhanye Mac, Kumar, Ashok, Sekar, Mahendran, Subramaniyan, Vetriselvan, Fuloria, Neeraj Kumar, Fuloria, Shivkanya, Velaga, Appalaraju, Sarker, Md. Moklesur Rahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475355/
https://www.ncbi.nlm.nih.gov/pubmed/37670975
http://dx.doi.org/10.7150/jca.85260
_version_ 1785100708929863680
author Goh, Khang Wen
Stephen, Annatasha
Wu, Yuan Seng
Sim, Maw Shin
Batumalaie, Kalaivani
Gopinath, Subash C.B.
Guad, Rhanye Mac
Kumar, Ashok
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Velaga, Appalaraju
Sarker, Md. Moklesur Rahman
author_facet Goh, Khang Wen
Stephen, Annatasha
Wu, Yuan Seng
Sim, Maw Shin
Batumalaie, Kalaivani
Gopinath, Subash C.B.
Guad, Rhanye Mac
Kumar, Ashok
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Velaga, Appalaraju
Sarker, Md. Moklesur Rahman
author_sort Goh, Khang Wen
collection PubMed
description Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers' generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications.
format Online
Article
Text
id pubmed-10475355
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-104753552023-09-05 Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms Goh, Khang Wen Stephen, Annatasha Wu, Yuan Seng Sim, Maw Shin Batumalaie, Kalaivani Gopinath, Subash C.B. Guad, Rhanye Mac Kumar, Ashok Sekar, Mahendran Subramaniyan, Vetriselvan Fuloria, Neeraj Kumar Fuloria, Shivkanya Velaga, Appalaraju Sarker, Md. Moklesur Rahman J Cancer Review Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers' generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications. Ivyspring International Publisher 2023-08-06 /pmc/articles/PMC10475355/ /pubmed/37670975 http://dx.doi.org/10.7150/jca.85260 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Goh, Khang Wen
Stephen, Annatasha
Wu, Yuan Seng
Sim, Maw Shin
Batumalaie, Kalaivani
Gopinath, Subash C.B.
Guad, Rhanye Mac
Kumar, Ashok
Sekar, Mahendran
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Velaga, Appalaraju
Sarker, Md. Moklesur Rahman
Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title_full Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title_fullStr Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title_full_unstemmed Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title_short Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
title_sort molecular targets of aptamers in gastrointestinal cancers: cancer detection, therapeutic applications, and associated mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475355/
https://www.ncbi.nlm.nih.gov/pubmed/37670975
http://dx.doi.org/10.7150/jca.85260
work_keys_str_mv AT gohkhangwen moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT stephenannatasha moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT wuyuanseng moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT simmawshin moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT batumalaiekalaivani moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT gopinathsubashcb moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT guadrhanyemac moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT kumarashok moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT sekarmahendran moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT subramaniyanvetriselvan moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT fulorianeerajkumar moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT fuloriashivkanya moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT velagaappalaraju moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms
AT sarkermdmoklesurrahman moleculartargetsofaptamersingastrointestinalcancerscancerdetectiontherapeuticapplicationsandassociatedmechanisms