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Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

Colorectal cancer (CRC) develops in part through the deregulation of different signaling pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally, the lysine methyltransferase enhancer of zeste homologue 2 (EZH2) is commonly overexpressed in CRC. EZH2 canonically repre...

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Detalles Bibliográficos
Autores principales:	Ghobashi, Ahmed H., Vuong, Truc T., Kimani, Jane W., Ladaika, Christopher A., Hollenhorst, Peter C., O’Hagan, Heather M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475482/ https://www.ncbi.nlm.nih.gov/pubmed/37670785 http://dx.doi.org/10.1016/j.isci.2023.107630

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