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Neutrophil swarming: Is a good offense the best defense?

The phenomenon of swarming has long been observed in nature as a strategic event that serves as a good offense toward prey and predators. Imaging studies have uncovered that neutrophils employ this swarm-like tactic within infected and inflamed tissues as part of the innate immune response. Much of...

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Detalles Bibliográficos
Autores principales: Brown, Luke, Yipp, Bryan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475518/
https://www.ncbi.nlm.nih.gov/pubmed/37670784
http://dx.doi.org/10.1016/j.isci.2023.107655
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author Brown, Luke
Yipp, Bryan G.
author_facet Brown, Luke
Yipp, Bryan G.
author_sort Brown, Luke
collection PubMed
description The phenomenon of swarming has long been observed in nature as a strategic event that serves as a good offense toward prey and predators. Imaging studies have uncovered that neutrophils employ this swarm-like tactic within infected and inflamed tissues as part of the innate immune response. Much of our understanding of neutrophil swarming builds from observations during sterile inflammation and various bacterial, fungal, and parasitic infections of the skin. However, the architecture and function of the skin differ significantly from vital organs where highly specialized microenvironments carry out critical functions. Therefore, the detrimental extent this perturbation may have on organ function remains unclear. In this review, we examine organ-specific swarming within the skin, liver, and lungs, with a detailed focus on swarming within microvascular environments. In addition, we examine potential “swarmulants” that initiate both transient and persistent swarms that have been implicated in disease.
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spelling pubmed-104755182023-09-05 Neutrophil swarming: Is a good offense the best defense? Brown, Luke Yipp, Bryan G. iScience Review The phenomenon of swarming has long been observed in nature as a strategic event that serves as a good offense toward prey and predators. Imaging studies have uncovered that neutrophils employ this swarm-like tactic within infected and inflamed tissues as part of the innate immune response. Much of our understanding of neutrophil swarming builds from observations during sterile inflammation and various bacterial, fungal, and parasitic infections of the skin. However, the architecture and function of the skin differ significantly from vital organs where highly specialized microenvironments carry out critical functions. Therefore, the detrimental extent this perturbation may have on organ function remains unclear. In this review, we examine organ-specific swarming within the skin, liver, and lungs, with a detailed focus on swarming within microvascular environments. In addition, we examine potential “swarmulants” that initiate both transient and persistent swarms that have been implicated in disease. Elsevier 2023-08-17 /pmc/articles/PMC10475518/ /pubmed/37670784 http://dx.doi.org/10.1016/j.isci.2023.107655 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Brown, Luke
Yipp, Bryan G.
Neutrophil swarming: Is a good offense the best defense?
title Neutrophil swarming: Is a good offense the best defense?
title_full Neutrophil swarming: Is a good offense the best defense?
title_fullStr Neutrophil swarming: Is a good offense the best defense?
title_full_unstemmed Neutrophil swarming: Is a good offense the best defense?
title_short Neutrophil swarming: Is a good offense the best defense?
title_sort neutrophil swarming: is a good offense the best defense?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475518/
https://www.ncbi.nlm.nih.gov/pubmed/37670784
http://dx.doi.org/10.1016/j.isci.2023.107655
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