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The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various gen...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475585/ https://www.ncbi.nlm.nih.gov/pubmed/37670983 http://dx.doi.org/10.3389/fmicb.2023.1233194 |
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author | Kolli, Udhghatri Roy, Sabita |
author_facet | Kolli, Udhghatri Roy, Sabita |
author_sort | Kolli, Udhghatri |
collection | PubMed |
description | The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use. |
format | Online Article Text |
id | pubmed-10475585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104755852023-09-05 The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome Kolli, Udhghatri Roy, Sabita Front Microbiol Microbiology The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use. Frontiers Media S.A. 2023-08-21 /pmc/articles/PMC10475585/ /pubmed/37670983 http://dx.doi.org/10.3389/fmicb.2023.1233194 Text en Copyright © 2023 Kolli and Roy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Kolli, Udhghatri Roy, Sabita The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title | The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title_full | The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title_fullStr | The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title_full_unstemmed | The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title_short | The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
title_sort | role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475585/ https://www.ncbi.nlm.nih.gov/pubmed/37670983 http://dx.doi.org/10.3389/fmicb.2023.1233194 |
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