Cargando…

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolli, Udhghatri, Roy, Sabita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475585/
https://www.ncbi.nlm.nih.gov/pubmed/37670983
http://dx.doi.org/10.3389/fmicb.2023.1233194
_version_ 1785100750656897024
author Kolli, Udhghatri
Roy, Sabita
author_facet Kolli, Udhghatri
Roy, Sabita
author_sort Kolli, Udhghatri
collection PubMed
description The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use.
format Online
Article
Text
id pubmed-10475585
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104755852023-09-05 The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome Kolli, Udhghatri Roy, Sabita Front Microbiol Microbiology The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use. Frontiers Media S.A. 2023-08-21 /pmc/articles/PMC10475585/ /pubmed/37670983 http://dx.doi.org/10.3389/fmicb.2023.1233194 Text en Copyright © 2023 Kolli and Roy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Kolli, Udhghatri
Roy, Sabita
The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title_full The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title_fullStr The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title_full_unstemmed The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title_short The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
title_sort role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475585/
https://www.ncbi.nlm.nih.gov/pubmed/37670983
http://dx.doi.org/10.3389/fmicb.2023.1233194
work_keys_str_mv AT kolliudhghatri theroleofthegutmicrobiomeandmicrobialmetabolisminmediatingopioidinducedchangesintheepigenome
AT roysabita theroleofthegutmicrobiomeandmicrobialmetabolisminmediatingopioidinducedchangesintheepigenome
AT kolliudhghatri roleofthegutmicrobiomeandmicrobialmetabolisminmediatingopioidinducedchangesintheepigenome
AT roysabita roleofthegutmicrobiomeandmicrobialmetabolisminmediatingopioidinducedchangesintheepigenome