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Advances in optical molecular imaging for neural visualization

Iatrogenic nerve injury is a significant complication in surgery, which can negatively impact patients’ quality of life. Currently, the main clinical neuroimaging methods, such as computed tomography, magnetic resonance imaging, and high-resolution ultrasonography, do not offer precise real-time pos...

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Autores principales: Wei, Jinzheng, Liu, Chao, Liang, Wenkai, Yang, Xiaofeng, Han, Shufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475611/
https://www.ncbi.nlm.nih.gov/pubmed/37671191
http://dx.doi.org/10.3389/fbioe.2023.1250594
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author Wei, Jinzheng
Liu, Chao
Liang, Wenkai
Yang, Xiaofeng
Han, Shufeng
author_facet Wei, Jinzheng
Liu, Chao
Liang, Wenkai
Yang, Xiaofeng
Han, Shufeng
author_sort Wei, Jinzheng
collection PubMed
description Iatrogenic nerve injury is a significant complication in surgery, which can negatively impact patients’ quality of life. Currently, the main clinical neuroimaging methods, such as computed tomography, magnetic resonance imaging, and high-resolution ultrasonography, do not offer precise real-time positioning images for doctors during surgery. The clinical application of optical molecular imaging technology has led to the emergence of new concepts such as optical molecular imaging surgery, targeted surgery, and molecular-guided surgery. These advancements have made it possible to directly visualize surgical target areas, thereby providing a novel method for real-time identification of nerves during surgery planning. Unlike traditional white light imaging, optical molecular imaging technology enables precise positioning and identifies the cation of intraoperative nerves through the presentation of color images. Although a large number of experiments and data support its development, there are few reports on its actual clinical application. This paper summarizes the research results of optical molecular imaging technology and its ability to realize neural visualization. Additionally, it discusses the challenges neural visualization recognition faces and future development opportunities.
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spelling pubmed-104756112023-09-05 Advances in optical molecular imaging for neural visualization Wei, Jinzheng Liu, Chao Liang, Wenkai Yang, Xiaofeng Han, Shufeng Front Bioeng Biotechnol Bioengineering and Biotechnology Iatrogenic nerve injury is a significant complication in surgery, which can negatively impact patients’ quality of life. Currently, the main clinical neuroimaging methods, such as computed tomography, magnetic resonance imaging, and high-resolution ultrasonography, do not offer precise real-time positioning images for doctors during surgery. The clinical application of optical molecular imaging technology has led to the emergence of new concepts such as optical molecular imaging surgery, targeted surgery, and molecular-guided surgery. These advancements have made it possible to directly visualize surgical target areas, thereby providing a novel method for real-time identification of nerves during surgery planning. Unlike traditional white light imaging, optical molecular imaging technology enables precise positioning and identifies the cation of intraoperative nerves through the presentation of color images. Although a large number of experiments and data support its development, there are few reports on its actual clinical application. This paper summarizes the research results of optical molecular imaging technology and its ability to realize neural visualization. Additionally, it discusses the challenges neural visualization recognition faces and future development opportunities. Frontiers Media S.A. 2023-08-21 /pmc/articles/PMC10475611/ /pubmed/37671191 http://dx.doi.org/10.3389/fbioe.2023.1250594 Text en Copyright © 2023 Wei, Liu, Liang, Yang and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wei, Jinzheng
Liu, Chao
Liang, Wenkai
Yang, Xiaofeng
Han, Shufeng
Advances in optical molecular imaging for neural visualization
title Advances in optical molecular imaging for neural visualization
title_full Advances in optical molecular imaging for neural visualization
title_fullStr Advances in optical molecular imaging for neural visualization
title_full_unstemmed Advances in optical molecular imaging for neural visualization
title_short Advances in optical molecular imaging for neural visualization
title_sort advances in optical molecular imaging for neural visualization
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475611/
https://www.ncbi.nlm.nih.gov/pubmed/37671191
http://dx.doi.org/10.3389/fbioe.2023.1250594
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