Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway

OBJECTIVE: Mechanical stress is an important risk factor for intervertebral disc degeneration (IVDD). Angiopoietin‐2 (ANG‐2) is regulated by mechanical stress and is widely involved in the regulation of extracellular matrix metabolism. In addition, the signaling cascade between HIF‐1α and NF‐κB is c...

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Detalles Bibliográficos
Autores principales: Ao, Xiang, Li, Yuan, Jiang, Tao, Li, Chenglong, Lian, Zhengnan, Wang, Liang, Zhang, Zhongmin, Huang, Minjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475680/
https://www.ncbi.nlm.nih.gov/pubmed/37475697
http://dx.doi.org/10.1111/os.13797

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