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Research Progress on the Pathogenesis of Knee Osteoarthritis

Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental heal...

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Autores principales: Du, Xin, Liu, Zi‐yu, Tao, Xing‐xing, Mei, Yong‐liang, Zhou, Da‐qian, Cheng, Kang, Gao, Si‐long, Shi, Hou‐yin, Song, Chao, Zhang, Xiao‐min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475681/
https://www.ncbi.nlm.nih.gov/pubmed/37435789
http://dx.doi.org/10.1111/os.13809
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author Du, Xin
Liu, Zi‐yu
Tao, Xing‐xing
Mei, Yong‐liang
Zhou, Da‐qian
Cheng, Kang
Gao, Si‐long
Shi, Hou‐yin
Song, Chao
Zhang, Xiao‐min
author_facet Du, Xin
Liu, Zi‐yu
Tao, Xing‐xing
Mei, Yong‐liang
Zhou, Da‐qian
Cheng, Kang
Gao, Si‐long
Shi, Hou‐yin
Song, Chao
Zhang, Xiao‐min
author_sort Du, Xin
collection PubMed
description Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro‐ and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment.
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spelling pubmed-104756812023-09-05 Research Progress on the Pathogenesis of Knee Osteoarthritis Du, Xin Liu, Zi‐yu Tao, Xing‐xing Mei, Yong‐liang Zhou, Da‐qian Cheng, Kang Gao, Si‐long Shi, Hou‐yin Song, Chao Zhang, Xiao‐min Orthop Surg Review Articles Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro‐ and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment. John Wiley & Sons Australia, Ltd 2023-07-12 /pmc/articles/PMC10475681/ /pubmed/37435789 http://dx.doi.org/10.1111/os.13809 Text en © 2023 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Du, Xin
Liu, Zi‐yu
Tao, Xing‐xing
Mei, Yong‐liang
Zhou, Da‐qian
Cheng, Kang
Gao, Si‐long
Shi, Hou‐yin
Song, Chao
Zhang, Xiao‐min
Research Progress on the Pathogenesis of Knee Osteoarthritis
title Research Progress on the Pathogenesis of Knee Osteoarthritis
title_full Research Progress on the Pathogenesis of Knee Osteoarthritis
title_fullStr Research Progress on the Pathogenesis of Knee Osteoarthritis
title_full_unstemmed Research Progress on the Pathogenesis of Knee Osteoarthritis
title_short Research Progress on the Pathogenesis of Knee Osteoarthritis
title_sort research progress on the pathogenesis of knee osteoarthritis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475681/
https://www.ncbi.nlm.nih.gov/pubmed/37435789
http://dx.doi.org/10.1111/os.13809
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