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IFN-γ: A Crucial Player in the Fight Against HBV Infection?

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death....

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Autores principales: Hillaire, Marine Laure Bettina, Lawrence, Philip, Lagrange, Brice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475827/
https://www.ncbi.nlm.nih.gov/pubmed/37670813
http://dx.doi.org/10.4110/in.2023.23.e30
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author Hillaire, Marine Laure Bettina
Lawrence, Philip
Lagrange, Brice
author_facet Hillaire, Marine Laure Bettina
Lawrence, Philip
Lagrange, Brice
author_sort Hillaire, Marine Laure Bettina
collection PubMed
description About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.
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spelling pubmed-104758272023-09-05 IFN-γ: A Crucial Player in the Fight Against HBV Infection? Hillaire, Marine Laure Bettina Lawrence, Philip Lagrange, Brice Immune Netw Review Article About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes. The Korean Association of Immunologists 2023-06-15 /pmc/articles/PMC10475827/ /pubmed/37670813 http://dx.doi.org/10.4110/in.2023.23.e30 Text en Copyright © 2023. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hillaire, Marine Laure Bettina
Lawrence, Philip
Lagrange, Brice
IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title_full IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title_fullStr IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title_full_unstemmed IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title_short IFN-γ: A Crucial Player in the Fight Against HBV Infection?
title_sort ifn-γ: a crucial player in the fight against hbv infection?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475827/
https://www.ncbi.nlm.nih.gov/pubmed/37670813
http://dx.doi.org/10.4110/in.2023.23.e30
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