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Treatment of congenital cytomegalovirus infection

Congenital cytomegalovirus (CMV) is the most common cause of congenital infection worldwide, the most common nongenetic cause of sensorineural hearing loss in children, and a cause of neurodevelopmental disorders in the brain. Infants with symptomatic congenital CMV infection may benefit from hearin...

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Autor principal: Shim, Gyu Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475861/
https://www.ncbi.nlm.nih.gov/pubmed/36596746
http://dx.doi.org/10.3345/cep.2022.01032
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author Shim, Gyu Hong
author_facet Shim, Gyu Hong
author_sort Shim, Gyu Hong
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description Congenital cytomegalovirus (CMV) is the most common cause of congenital infection worldwide, the most common nongenetic cause of sensorineural hearing loss in children, and a cause of neurodevelopmental disorders in the brain. Infants with symptomatic congenital CMV infection may benefit from hearing and neurodevelopmental outcomes, particularly if antiviral treatment is initiated within the first month of life. Infants with life-threatening symptoms are recommended to receive 2–6 weeks of intravenous ganciclovir and then switch to oral valganciclovir, and those without life-threatening symptoms are recommended to use oral valganciclovir during the entire 6-month period. During antiviral drug treatment, absolute neutrophil count, platelet count, blood urea nitrogen, creatinine, and liver function tests were performed to identify neutropenia, thrombocytopenia, renal failure, and liver failure. This review investigated the evidence to date of treating congenital CMV infection.
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spelling pubmed-104758612023-09-05 Treatment of congenital cytomegalovirus infection Shim, Gyu Hong Clin Exp Pediatr Review Article Congenital cytomegalovirus (CMV) is the most common cause of congenital infection worldwide, the most common nongenetic cause of sensorineural hearing loss in children, and a cause of neurodevelopmental disorders in the brain. Infants with symptomatic congenital CMV infection may benefit from hearing and neurodevelopmental outcomes, particularly if antiviral treatment is initiated within the first month of life. Infants with life-threatening symptoms are recommended to receive 2–6 weeks of intravenous ganciclovir and then switch to oral valganciclovir, and those without life-threatening symptoms are recommended to use oral valganciclovir during the entire 6-month period. During antiviral drug treatment, absolute neutrophil count, platelet count, blood urea nitrogen, creatinine, and liver function tests were performed to identify neutropenia, thrombocytopenia, renal failure, and liver failure. This review investigated the evidence to date of treating congenital CMV infection. Korean Pediatric Society 2022-12-28 /pmc/articles/PMC10475861/ /pubmed/36596746 http://dx.doi.org/10.3345/cep.2022.01032 Text en Copyright © 2023 by The Korean Pediatric Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shim, Gyu Hong
Treatment of congenital cytomegalovirus infection
title Treatment of congenital cytomegalovirus infection
title_full Treatment of congenital cytomegalovirus infection
title_fullStr Treatment of congenital cytomegalovirus infection
title_full_unstemmed Treatment of congenital cytomegalovirus infection
title_short Treatment of congenital cytomegalovirus infection
title_sort treatment of congenital cytomegalovirus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475861/
https://www.ncbi.nlm.nih.gov/pubmed/36596746
http://dx.doi.org/10.3345/cep.2022.01032
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