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Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease
Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While mul...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475950/ https://www.ncbi.nlm.nih.gov/pubmed/37671044 http://dx.doi.org/10.3389/fgene.2023.1243395 |
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author | Agredo, Alejandra Kasinski, Andrea L. |
author_facet | Agredo, Alejandra Kasinski, Andrea L. |
author_sort | Agredo, Alejandra |
collection | PubMed |
description | Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While multiple histone PTMs are studied and often work in concert to facilitate gene expression, here we focus on the tri-methylation of histone H4 on lysine 20 (H4K20me3) and its function in chromatin structure, cell cycle, DNA repair, and development. The recent studies evaluated in this review have shed light on how H4K20me3 is established and regulated by various interacting partners and how H4K20me3 and the proteins that interact with this PTM are involved in various diseases. Through analyzing the current literature on H4K20me3 function and regulation, we aim to summarize this knowledge and highlights gaps that remain in the field. |
format | Online Article Text |
id | pubmed-10475950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104759502023-09-05 Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease Agredo, Alejandra Kasinski, Andrea L. Front Genet Genetics Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell homeostasis. A great deal of this regulation is dependent on histone proteins which have the ability to be dynamically modified on their tails via various post-translational modifications (PTMs). While multiple histone PTMs are studied and often work in concert to facilitate gene expression, here we focus on the tri-methylation of histone H4 on lysine 20 (H4K20me3) and its function in chromatin structure, cell cycle, DNA repair, and development. The recent studies evaluated in this review have shed light on how H4K20me3 is established and regulated by various interacting partners and how H4K20me3 and the proteins that interact with this PTM are involved in various diseases. Through analyzing the current literature on H4K20me3 function and regulation, we aim to summarize this knowledge and highlights gaps that remain in the field. Frontiers Media S.A. 2023-08-21 /pmc/articles/PMC10475950/ /pubmed/37671044 http://dx.doi.org/10.3389/fgene.2023.1243395 Text en Copyright © 2023 Agredo and Kasinski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Agredo, Alejandra Kasinski, Andrea L. Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title_full | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title_fullStr | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title_full_unstemmed | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title_short | Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
title_sort | histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475950/ https://www.ncbi.nlm.nih.gov/pubmed/37671044 http://dx.doi.org/10.3389/fgene.2023.1243395 |
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