Aberrant PI3Kδ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers

INTRODUCTION: PI3K/AKT signaling pathway is upregulated in a broad spectrum of cancers. Among the class I PI3Ks (PI3Kδ/β/δ isoforms), PI3Kδ has been implicated in hematologic cancers and solid tumors. Alternative splicing is a post-transcriptional process for acquiring proteomic diversity in eukaryo...

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Detalles Bibliográficos
Autores principales: Ha, Siyoung, Gujrati, Himali, Wang, Bi-Dar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475954/
https://www.ncbi.nlm.nih.gov/pubmed/37670888
http://dx.doi.org/10.3389/fendo.2023.1190479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475954/
https://www.ncbi.nlm.nih.gov/pubmed/37670888
http://dx.doi.org/10.3389/fendo.2023.1190479

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