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Aberrant PI3Kδ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
INTRODUCTION: PI3K/AKT signaling pathway is upregulated in a broad spectrum of cancers. Among the class I PI3Ks (PI3Kδ/β/δ isoforms), PI3Kδ has been implicated in hematologic cancers and solid tumors. Alternative splicing is a post-transcriptional process for acquiring proteomic diversity in eukaryo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475954/ https://www.ncbi.nlm.nih.gov/pubmed/37670888 http://dx.doi.org/10.3389/fendo.2023.1190479 |