A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

A novel tetranuclear Cu(ii) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indic...

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Detalles Bibliográficos
Autores principales: Cao, Shuhua, Wang, Anlin, Li, Kaoxue, Lin, Zhiteng, Yang, Hongwei, Zhang, Xiaolei, Qiu, Jianmei, Tai, Xishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476018/
https://www.ncbi.nlm.nih.gov/pubmed/37671352
http://dx.doi.org/10.1039/d3ra03624c
Descripción
Sumario:A novel tetranuclear Cu(ii) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indicated that TNC could bind to the DNA through an intercalative mode. The agarose gel electrophoresis experiment showed that TNC could cleave supercoiled plasmid DNA into linear DNA. The anticancer activity of TNC was tested on four cancer cell lines: MCF7, A549, 4T1 and HepG2. The results indicated that TNC shown significant activity against all of above cell lines.

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