A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity

A novel tetranuclear Cu(ii) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indic...

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Autores principales: Cao, Shuhua, Wang, Anlin, Li, Kaoxue, Lin, Zhiteng, Yang, Hongwei, Zhang, Xiaolei, Qiu, Jianmei, Tai, Xishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476018/
https://www.ncbi.nlm.nih.gov/pubmed/37671352
http://dx.doi.org/10.1039/d3ra03624c
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author Cao, Shuhua
Wang, Anlin
Li, Kaoxue
Lin, Zhiteng
Yang, Hongwei
Zhang, Xiaolei
Qiu, Jianmei
Tai, Xishi
author_facet Cao, Shuhua
Wang, Anlin
Li, Kaoxue
Lin, Zhiteng
Yang, Hongwei
Zhang, Xiaolei
Qiu, Jianmei
Tai, Xishi
author_sort Cao, Shuhua
collection PubMed
description A novel tetranuclear Cu(ii) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indicated that TNC could bind to the DNA through an intercalative mode. The agarose gel electrophoresis experiment showed that TNC could cleave supercoiled plasmid DNA into linear DNA. The anticancer activity of TNC was tested on four cancer cell lines: MCF7, A549, 4T1 and HepG2. The results indicated that TNC shown significant activity against all of above cell lines.
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spelling pubmed-104760182023-09-05 A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity Cao, Shuhua Wang, Anlin Li, Kaoxue Lin, Zhiteng Yang, Hongwei Zhang, Xiaolei Qiu, Jianmei Tai, Xishi RSC Adv Chemistry A novel tetranuclear Cu(ii) complex (TNC) was successfully synthesized and characterized by X-ray single crystal diffraction. The interaction of the complex with calf thymus DNA (CT-DNA) has been studied by UV-vis absorption titration, fluorescence technology and molecular docking. The results indicated that TNC could bind to the DNA through an intercalative mode. The agarose gel electrophoresis experiment showed that TNC could cleave supercoiled plasmid DNA into linear DNA. The anticancer activity of TNC was tested on four cancer cell lines: MCF7, A549, 4T1 and HepG2. The results indicated that TNC shown significant activity against all of above cell lines. The Royal Society of Chemistry 2023-09-04 /pmc/articles/PMC10476018/ /pubmed/37671352 http://dx.doi.org/10.1039/d3ra03624c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cao, Shuhua
Wang, Anlin
Li, Kaoxue
Lin, Zhiteng
Yang, Hongwei
Zhang, Xiaolei
Qiu, Jianmei
Tai, Xishi
A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title_full A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title_fullStr A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title_full_unstemmed A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title_short A novel tetranuclear Cu(ii) complex for DNA-binding and in vitro anticancer activity
title_sort novel tetranuclear cu(ii) complex for dna-binding and in vitro anticancer activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476018/
https://www.ncbi.nlm.nih.gov/pubmed/37671352
http://dx.doi.org/10.1039/d3ra03624c
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