Development of substituted benzylidene derivatives as novel dual cholinesterase inhibitors for Alzheimer's treatment

Leading pathological markers of Alzheimer's disease (AD) include Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), Amyloid beta (Aβ) and reactive oxygen species (ROS). Indole derivatives were identified and optimized to improve the potency against AChE, BuChE, Aβ and ROS. The lead mol...

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Detalles Bibliográficos
Autores principales: Gupta, Shraddha Manish, Behera, Ashok, Jain, Neetesh K., Tripathi, Avanish, Rishipathak, Dinesh, Singh, Siddharth, Ahemad, Nafees, Erol, Meryem, Kumar, Devendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476022/
https://www.ncbi.nlm.nih.gov/pubmed/37671344
http://dx.doi.org/10.1039/d3ra03224h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476022/
https://www.ncbi.nlm.nih.gov/pubmed/37671344
http://dx.doi.org/10.1039/d3ra03224h

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