Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation

[Image: see text] Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5H)-ones in 59–88% yields. Furthermore...

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Autores principales: Geng, Xin, He, Heng, Shatskiy, Andrey, Stepanova, Elena V., Alvey, Gregory R., Liu, Jian-Quan, Kärkäs, Markus D., Wang, Xiang-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476191/
https://www.ncbi.nlm.nih.gov/pubmed/37611263
http://dx.doi.org/10.1021/acs.joc.3c01429
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author Geng, Xin
He, Heng
Shatskiy, Andrey
Stepanova, Elena V.
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
author_facet Geng, Xin
He, Heng
Shatskiy, Andrey
Stepanova, Elena V.
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
author_sort Geng, Xin
collection PubMed
description [Image: see text] Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5H)-ones in 59–88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments.
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spelling pubmed-104761912023-09-05 Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation Geng, Xin He, Heng Shatskiy, Andrey Stepanova, Elena V. Alvey, Gregory R. Liu, Jian-Quan Kärkäs, Markus D. Wang, Xiang-Shan J Org Chem [Image: see text] Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5H)-ones in 59–88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments. American Chemical Society 2023-08-23 /pmc/articles/PMC10476191/ /pubmed/37611263 http://dx.doi.org/10.1021/acs.joc.3c01429 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Geng, Xin
He, Heng
Shatskiy, Andrey
Stepanova, Elena V.
Alvey, Gregory R.
Liu, Jian-Quan
Kärkäs, Markus D.
Wang, Xiang-Shan
Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title_full Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title_fullStr Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title_full_unstemmed Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title_short Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
title_sort construction of phenanthridinone skeletons through palladium-catalyzed annulation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476191/
https://www.ncbi.nlm.nih.gov/pubmed/37611263
http://dx.doi.org/10.1021/acs.joc.3c01429
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