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Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts

T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic tumor, characterized by several genetic alterations, that constitutes 15% of pediatric and 25% of adult ALL. While with current therapeutic protocols children and adults’ overall survival (OS) rates reach 85–90% and 40–50%, respectively, t...

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Detalles Bibliográficos
Autores principales:	Minuzzo, Sonia, Agnusdei, Valentina, Pinazza, Marica, Amaro, Adriana A., Sacchetto, Valeria, Pfeffer, Ulrich, Bertorelle, Roberta, Spinelli, Orietta, Serafin, Valentina, Indraccolo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Correspondence
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476325/ https://www.ncbi.nlm.nih.gov/pubmed/37667380 http://dx.doi.org/10.1186/s40164-023-00439-6

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