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Lipid rafts and human diseases: why we need to target gangliosides
Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic strategies. Beginning with a discussion of what a di...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476576/ https://www.ncbi.nlm.nih.gov/pubmed/37052878 http://dx.doi.org/10.1002/2211-5463.13612 |
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author | Fantini, Jacques |
author_facet | Fantini, Jacques |
author_sort | Fantini, Jacques |
collection | PubMed |
description | Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic strategies. Beginning with a discussion of what a disease is (and is not), this review lists the major human pathologies that involve gangliosides, which includes cancer, diabetes, and infectious and neurodegenerative diseases. In most cases, the problem is due to a protein whose binding to gangliosides either creates a pathological condition or impairs a physiological function. Then, I draw up an inventory of the different molecular mechanisms of protein‐ganglioside interactions. I propose to classify the ganglioside‐binding domains of proteins into four categories, which I name GBD‐1, GBD‐2, GBD‐3, and GBD‐4. This structural and functional classification could help to rationalize the design of innovative molecules capable of disrupting the binding of selected proteins to gangliosides without generating undesirable effects. The biochemical specificities of gangliosides expressed in the human brain must also be taken into account to improve the reliability of animal models (or any animal‐free alternative) of Alzheimer's and Parkinson's diseases. |
format | Online Article Text |
id | pubmed-10476576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104765762023-09-05 Lipid rafts and human diseases: why we need to target gangliosides Fantini, Jacques FEBS Open Bio Reviews Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic strategies. Beginning with a discussion of what a disease is (and is not), this review lists the major human pathologies that involve gangliosides, which includes cancer, diabetes, and infectious and neurodegenerative diseases. In most cases, the problem is due to a protein whose binding to gangliosides either creates a pathological condition or impairs a physiological function. Then, I draw up an inventory of the different molecular mechanisms of protein‐ganglioside interactions. I propose to classify the ganglioside‐binding domains of proteins into four categories, which I name GBD‐1, GBD‐2, GBD‐3, and GBD‐4. This structural and functional classification could help to rationalize the design of innovative molecules capable of disrupting the binding of selected proteins to gangliosides without generating undesirable effects. The biochemical specificities of gangliosides expressed in the human brain must also be taken into account to improve the reliability of animal models (or any animal‐free alternative) of Alzheimer's and Parkinson's diseases. John Wiley and Sons Inc. 2023-04-20 /pmc/articles/PMC10476576/ /pubmed/37052878 http://dx.doi.org/10.1002/2211-5463.13612 Text en © 2023 The Author. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Fantini, Jacques Lipid rafts and human diseases: why we need to target gangliosides |
title | Lipid rafts and human diseases: why we need to target gangliosides |
title_full | Lipid rafts and human diseases: why we need to target gangliosides |
title_fullStr | Lipid rafts and human diseases: why we need to target gangliosides |
title_full_unstemmed | Lipid rafts and human diseases: why we need to target gangliosides |
title_short | Lipid rafts and human diseases: why we need to target gangliosides |
title_sort | lipid rafts and human diseases: why we need to target gangliosides |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476576/ https://www.ncbi.nlm.nih.gov/pubmed/37052878 http://dx.doi.org/10.1002/2211-5463.13612 |
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