The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry

BACKGROUND: The synergistic effect of dihydromyricetin (DHM) and fluconazole (FLC) can improve the killing effect of FLC-resistant Candida albicans in vitro and in vivo. However, it is not clear whether DHM affects the pharmacokinetic characteristics of FLC. METHODS: In this study, 12 Sprague–Dawley...

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Detalles Bibliográficos
Autores principales: Liu, Hongchuan, Dong, Huaihuai, Guo, Liangjun, Jin, Yongsheng, Liu, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476617/
https://www.ncbi.nlm.nih.gov/pubmed/37670905
http://dx.doi.org/10.2147/DDDT.S415813

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